年轻卵巢功能减退患者使用微刺激方案和高孕激素促排卵方案IVF-ET的疗效比较OACSTPCD

Objective:To compare the clinical outcome of progestin-primed ovarian stimulation(PPOS)with mild stimulation protocol in young patients with diminished ovarian re-serve(DOR)undergoing in vitro fertilization cycle(IVF-ET).Methods:The data of 147 young patients(under 35 years old)with DOR who underwent IVF-ET in the Affiliated Taizhou Peoples Hospital of Nanjing Medical University between October 2019 and October 2022 were analyzed restropectively,108 of whom received PPOS protocol while 39 patients received mild stimulation protocol.Comparisons of the basic information,ovarian stimulation status,laboratory parameters,abnormal conditions in treatment and clinical outcomes between two groups were performed by univariable analysis.Result:A greater amount of total gonadotropin,longer dura-tion of stimulation,higher Estradiol on HCG day,higher number of retrieved oocytes and lower value of luteinizing hormone(LH)were observed in the PPOS group(P<0.05).The normal fertilization rate was higher in the mild stimulation group than that in the PPOS group(P= 0.013).There were no significant differences of the abnormal conditions in the treatment and clinical outcomes between the two groups(all P>0.05).Conclusions:Although a lower risk of premature luteinizing hormone(LH)surge and a higher number of retrieved oocytes were ob-served in the PPOS group,either the duration of stimulation or the amount of total gonadotropin was greater in PPOS group than those in the mild stimulation protocol group.In addition,the normal fertilization rate was lower in the PPOS group.The clinical outcome of patients underg-one PPOS protocol was no better than that of the mild stimulation protocol.So,as a protocol which maybe more economical and closer to the natural ovulation cycle compared with the PPOS protocol,the mild stimulation protocol may be a better choice for young patients with DOR un-dergoing IVF-ET.