摘要
Abstract
Objective To explore the effect of nimodipine combined with donepezil hydrochloride on the short-term prognosis of patients with cerebral small vessel cognitive impairment.Methods 88 patients with cognitive impairment caused by cerebrovascular disease treated in Hebi People's Hospital from November 2020 to December 2022 were randomly divided into two groups.The control group was treated with donepezil hydrochloride,and the observation group was treated with nimodipine and donepezil hydrochloride.The treatment effect,neurological function,cognitive function,and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was 97.73％,significantly higher than 81.82％ in the control group(P＜0.05)).After 3 months of treatment,the NIHSS score of the observation group was lower than that of the control group,and the MoCA score was higher than that of the control group(P＜0.05).The incidence of adverse reactions in the observation group was 9.09％,without signifiicant difference compared to 6.82％ in the control group(P＞0.05).Conclusions The combination of nimodipine and donepezil hydrochloride has better effect on cerebral small vessel cognitive impairment,which can effectively improve the neurological and cognitive functions of patients,with higher safety,and is worthy of clinical application and promotion.关键词
尼莫地平/盐酸多奈哌齐/脑小血管病性认知障碍/认知功能Key words
Nimodipine/Donepezil hydrochloride/Cerebral small vessel cognitive impairment/Cognitive function分类
医药卫生
