医学信息2024，Vol.37Issue(1)：130-134,5.DOI:10.3969/j.issn.1006-1959.2024.01.022
纤维蛋白原/前白蛋白比值与多发性骨髓瘤患者预后的关系
Relationship Between the Fibrinogen/pre-albumin Ratio and the Prognosis of Patients with Multiple Myeloma
刘北 1夏海龙 2焦燕 1张慧敏1
作者信息
- 1. 安徽医科大学附属巢湖医院血液科,安徽 巢湖 238000
- 2. 安徽医科大学附属巢湖医院血液科,安徽 巢湖 238000||安徽医科大学第一附属医院血液科,安徽 合肥 230022
- 折叠
摘要
Abstract
Objective To investigate the relationship between fibrinogen/pre-albumin ratio(FPR)and prognosis of patients with newly diagnosed multiple myeloma(MM).Methods A retrospective analysis of 100 newly diagnosed MM patients in Chaohu Hospital of Anhui Medical University and the First Affiliated Hospital of Anhui Medical University from January 2015 to January 2022 was performed.The clinical data of the patients were collected,and the best cut-off value of FPR was calculated by the receiver operating characteristic curve(ROC).According to the optimal cut-off value of FPR,the patients were divided into high FPR group(56 patients)and low FPR group(44 patients).The overall survival time(OS)and progression-free survival time(PFS)were compared between the two groups,and the risk factors affecting the disease progression of newly diagnosed multiple myeloma patients were analyzed by univariate and multivariate analysis.Results The best cut-off value of ROC curve was 0.0168.There were significant differences in ISS stage,β2-MG,hemoglobin,serum calcium,bone marrow plasma cell ratio and classification between high FPR group and low FPR group(P＜0.05).Univariate analysis showed that ISS stage,FPR,albumin,bone marrow plasma cell ratio and efficacy after 4 courses of treatment were the influencing factors of OS and PFS in newly diagnosed MM patients(P＜0.05).Multivariate analysis showed that ISS stage,FPR,albumin,and efficacy after 4 courses of treatment were independent risk factors for PFS in newly diagnosed MM patients(P＜0.05).ISS stage,FPR,albumin,bone marrow plasma cell ratio and efficacy after 4 courses of treatment were independent risk factors for OS in newly diagnosed MM patients(P＜0.05).Conclusion FPR is an independent risk factor affecting OS in newly diagnosed MM patients,and high FPR indicates poor prognosis.关键词
多发性骨髓瘤/FPR/预后Key words
Multiple myeloma/FPR/Prognosis分类
医药卫生引用本文复制引用
刘北,夏海龙,焦燕,张慧敏..纤维蛋白原/前白蛋白比值与多发性骨髓瘤患者预后的关系[J].医学信息,2024,37(1):130-134,5.
