医学信息2024，Vol.37Issue(1)：135-139,5.DOI:10.3969/j.issn.1006-1959.2024.01.023
合成MRI联合3D-ASL在阿尔兹海默病诊断中的价值
Value of Synthetic MRI Combined with 3D-ASL in the Diagnosis of Alzheimer's Disease
童玉洁 1翟冬枝 1李真真 1刘华1
作者信息
- 1. 郑州大学第二附属医院医学影像科,河南 郑州 450000
- 折叠
摘要
Abstract
Objective To investigate the changes of quantitative values of bilateral hippocampus in AD by synthetic magnetic resonance imaging(SynMRI)combined with three-dimensional arterial spin labeling(3D-ASL)sequence,and to study the value of the combination of the two in the early diagnosis of Alzheimer's disease(AD).Methods A total of 24 patients with Alzheimer's disease diagnosed clinically in the Second Affiliated Hospital of Zhengzhou University from January 2022 to June 2022 were prospectively enrolled as Alzheimer's disease group(AD group),at the same time,26 healthy people who came to the Second Affiliated Hospital of Zhengzhou University for physical examination were included as the healthy control group(HC group)for this experiment under the condition of matching age、gender and education level.All subjects were scanned with MAGiC sequence and 3D-ASL sequence on 3.0T GE MRI scanner,and double-test hippocampus was selected as the region of interest(region of interest,ROI).The values of T1,T2,PD and CBF in their regions of interest were measured,and all subjects received mini mental state examination(MMSE)score.The bilateral hippocampal values of the AD group and the HC group were recorded,and Pearson correlation analysis was carried out between these quantitative parameters and MMSE score.Results There was no significant difference in T1 and PD values between AD group and HC group(P＞0.05).The T2 value of the AD group was higher than that of the HC group,while the CBF value was lower than that of the HC group(P＜0.05).With the decrease of MMSE score in AD patients,the T1 value and T2 value of bilateral hippocampus increased,and the CBF value decreased(P＜0.05).Conclusion Synthetic MRI combined with 3D-ASL has a good quantitative value in the bilateral hippocampus of AD patients,which can be used for early diagnosis of AD.关键词
阿尔兹海默病/合成MRI/3D-ASL/弛豫值/脑血流量Key words
Alzheimer's disease/Synthetic MRI/3D-ASL/Relaxation value/Cerebral blood flow分类
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童玉洁,翟冬枝,李真真,刘华..合成MRI联合3D-ASL在阿尔兹海默病诊断中的价值[J].医学信息,2024,37(1):135-139,5.
