侯亚坤 1黄新 1周星宇 1陶宁 1安恒庆 1王文光1
作者信息
- 1. 新疆医科大学第一附属医院泌尿外科,新疆 乌鲁木齐 830054
- 折叠
摘要
Abstract
Objective To investigate the effect of endocrine therapy in patients with pathological stage＜T3,lymph node negative,negative margin,negative vascular invasion and immediate postoperative PSA reduction＜0.1 ng/ml after localized high-risk radical prostatectomy.Methods A retrospective analysis of 90 patients with localized high-risk prostate cancer who underwent laparoscopic radical prostatectomy in our hospital from January 2016 to December 2022 and whose postoperative pathological features met pathological stage＜T3,negative lymph node,negative margin,negative vascular invasion,and PSA decreased to＜0.1 ng/ml immediately after surgery.According to different treatment options,they were divided into laparoscopic radical prostatectomy+endocrine therapy(RP+ADT)group and laparoscopic radical prostatectomy follow-up(RP)group,with 45 patients in each group.The total biochemical recurrence rate,1-year,2-year,3-year biochemical recurrence rate,PSA progression-free survival,and adverse reactions of endocrine therapy were compared between the two groups.Results There was no significant difference in the total biochemical recurrence rate,1-year,2-year,3-year biochemical recurrence rate and PSA progression-free survival between the two groups(P＞0.05).In the RP+ADT group,1 case had mild gross hematuria after endocrine therapy,and recovered after 1 month;13 cases had hot flashes,3 cases had hepatotoxicity(mild transaminase elevation),1 case had osteoporosis and 1 case had cerebral infarction.The number of adverse reactions of endocrine therapy was small and could not be statistically analyzed.Conclusion For patients with localized high-risk prostate cancer whose pathological features meet the pathological stage＜T3,lymph node negative,negative margin,negative vascular invasion and immediate postoperative PSA reduction to＜0.1 ng/ml,it is recommended to follow up for 3 years after surgery.After 3 years,follow-up treatment is determined according to the increase of PSA in patients.关键词
高危前列腺癌/腹腔镜下前列腺癌根治术/病理特征阴性/内分泌治疗Key words
High-risk prostate cancer/Laparoscopic radical prostatectomy/Negative pathological features/Endocrine therapy分类
医药卫生
