Hcy、HSP70、H-FABP对脑梗死患者的疗效评估作用OA
Efficacy Evaluation of Hcy,HSP70 and H-FABP in Patients with Cerebral Infarction
目的 探讨同型半胱氨酸(Hcy)、热休克蛋白 70(HSP70)、心型脂肪酸结合蛋白(H-FABP)对丁苯酞联合通窍活血汤治疗脑梗死患者的疗效评估作用.方法 选取鹿邑县人民医院 2021 年 10 月至 2022 年 10 月收治的 82 例脑梗死患者作为研究对象,给予丁苯酞联合通窍活血汤治疗.比较有效组和无效组的临床资料及血清学指标,Logistic回归分析影响治疗效果的因素,分析血清Hcy、HSP70、H-FABP单独及联合检测预测治疗效果的价值并编制ROC曲线.结果 治疗 14 d后,显效 38 例、有效 30 例、无效 14 例,治疗有效率为 82.93%.其中有效组 68 例,无效组 14例;有效组Hcy、HSP70、H-FABP水平均低于无效组;Hcy、HSP70、H-FABP均是影响脑梗死患者治疗效果的危险因素;血清Hcy、HSP70、H-FABP联合检测预测治疗效果的AUC值高于单项检测,差异有统计学意义(ZHcy=3.038,ZHSP70=2.411,ZH-FABP=2.352,P＜0.05).结论 血清Hcy、HSP70、H-FABP联合检测对丁苯酞联合通窍活血汤治疗的脑梗死患者的临床疗效具有一定预测价值.
Objective To evaluate the effects of homocysteine(Hcy),heat shock protein 70(HSP70)and cardiac fatty acid binding protein(H-FABP)on the treatment of cerebral infarction with butylphthalein combined with Tongqiao Huoxue Decoction.Methods A total of 82 patients with cerebral infarction admitted to People's Hospital of Luyi County from October 2021 to October 2022 were selected as the research objects,and treated with butylphthalein combined with Tongqiaohuoxuene decoction.The clinical data and serological indexes of the effective group and the ineffective group were compared,the factors influencing the therapeutic effect were analyzed by Logistic regression,and the value of serum Hcy,HSP70 and H-FABP alone and combined in predicting the therapeutic effect was analyzed,and the ROC curve was prepared.Results After 14 days of treatment,38 cases were obviously effective,30 cases were effective,14 cases were ineffective,and the total effective rate was 82.93%.There were 68 cases in the effective group and 14 cases in the ineffective group.The levels of Hcy,HSP70 and H-FABP in effective group were lower than those in ineffective group.The Hcy,HSP70 and H-FABP were all risk factors affecting the therapeutic effect of cerebral infarction patients.The AUC value of serum Hcy,HSP70 and H-FABP combined test was higher than that of single test,and the difference was statistically significant(ZHcy=3.038,ZHSP70=2.411,ZH-FABP=2.352,P＜0.05).Conclusion The combined detection of serum Hcy,HSP70 and H-FABP has a certain predictive value for the clinical efficacy of butylphthalein combined with Tongqiao Huoxue Decoction in the treatment of cerebral infarction patients.
尹慧敏;丁秋勤;贾红丽
鹿邑县人民医院 神经内科一病区,河南 周口 477200周口市中心医院 急诊科,河南 周口 466000
临床医学
脑梗死丁苯酞通窍活血汤同型半胱氨酸热休克蛋白70心型脂肪酸结合蛋白
cerebral infarctionbutylphthaleinTongqiao activating blood decoctionhomocysteineheat shock protein 70heart fatty acid binding protein
《临床研究》 2024 (001)
23-26 / 4
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