眼科新进展2024，Vol.44Issue(1)：1-12,12.DOI:10.13389/j.cnki.rao.2024.0001
炎症在糖尿病视网膜病变中的作用:发病机制及治疗策略
Role of inflammation in diabetic retinopathy:pathogenesis and treatment strategies
摘要
Abstract
Diabetic retinopathy(DR)is considered to be a chronic medium-and low-grade inflammatory disease(mi-croinflammation).Inflammation runs through the entire process of DR,manifesting as an increase in ocular and systemic inflammation biomarkers.In the eyes of DR patients,there is an increase in pro-inflammatory mediators,such as interleu-kin(IL)-1 β,IL-6 and tumor necrosis factor-α,as well as activated and increased number of inflammatory cells,such as ac-tivated microglia,Müller cells in the retina,and infiltration of mononuclear macrophage.In addition,immunocytes are also involved in the pathogenesis of DR,such as the involvement of circulating T cells in leukostasis.These indicate that chronic inflammation is an inducing factor of DR,with multiple inflammation-related factors participating and influencing each other,leading to the destruction of the blood-retinal barrier and neuronal injury and exacerbating the development of DR.There-fore,personalized anti-inflammatory therapy is of great significance in the treatment of DR.关键词
糖尿病视网膜病变/炎症/炎症因子/炎症细胞/小胶质细胞Key words
diabetic retinopathy/inflammation/inflammatory factors/inflammatory cells/microglia分类
医药卫生引用本文复制引用
张敬法..炎症在糖尿病视网膜病变中的作用:发病机制及治疗策略[J].眼科新进展,2024,44(1):1-12,12.基金项目
国家自然科学基金(编号:82171062) （编号:82171062）
