电针通过调控TLR4介导的炎症信号通路改善糖尿病干眼大鼠角膜炎症的机制研究OACSTPCD
Mechanism of electroacupuncture on improving corneal inflammation in dia-betic dry eye rats by regulating Toll-like receptor 4-mediated inflammatory signaling pathway
目的 观察电针对糖尿病干眼大鼠角膜Toll样受体4(TLR4)介导的炎症信号通路的影响,探讨电针治疗糖尿病干眼的作用机制.方法 健康雄性SD大鼠32只采用高糖高脂饲料喂养4周后,腹腔注射链脲佐菌素(30 mg·kg-1)12周建立2型糖尿病大鼠模型.将造模成功的25只糖尿病干眼大鼠随机分为模型组(不做干预)、电针组(选取"睛明""攒竹""丝竹空""太阳""瞳子髎"针刺,电针接"攒竹""瞳子髎",每次15 min,每天1次)、假针刺组(穴位刺激处同…查看全部>>
Objective To observe the effect of electroacupuncture on corneal Toll-like receptor 4(TLR4)-mediated inflammatory signaling pathway in diabetic dry eye rats and to explore the mechanism of electroacupuncture in the treat-ment of diabetic dry eye.Methods A type 2 diabetic rat model was established in 32 healthy male Sprague-Dawley(SD)rats by intraperitoneal injection of streptozotocin(30 mg·kg-1)for 12 weeks after feeding with high-sugar and high-fat di-et fo…查看全部>>
傅张倚天;万咪咪;赖思华;孙心怡;李小颖;高卫萍
210024 江苏省南京市,南京中医药大学附属医院眼科210024 江苏省南京市,南京中医药大学附属医院眼科210024 江苏省南京市,南京中医药大学附属医院针灸康复科210024 江苏省南京市,南京中医药大学附属医院内分泌科210024 江苏省南京市,南京中医药大学附属医院眼科210024 江苏省南京市,南京中医药大学附属医院眼科
临床医学
干眼2型糖尿病炎症电针Toll样受体4核因子κB
dry eyetype 2 diabetesinflammationelectroacupunctureToll-like receptor 4nuclear factor kappa-B
《眼科新进展》 2024 (1)
针刺调控P2X3受体介导的PKC/NMDA信号通路缓解干眼眼表神经痛的分子机制研究
24-29,6
国家自然科学基金(编号:82074526)
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