医药导报2024，Vol.43Issue(1)：106-114,9.DOI:10.3870/j.issn.1004-0781.2024.01.017
中药单体调控非受体型酪氨酸激酶抗肿瘤的研究进展
Research Progress of Chinese Medicine Monomers with Anti-tumor Effect by Regulating Non-receptor Tyrosine Kinase
摘要
Abstract
Cancer is a severe threat to human life and health.The over-activation of oncogenes is the main reason for poor treatment and prognosis of cancer patients.Most of these over-activated oncogenes are protein tyrosine kinase(PTK).Among many PTKs,non-receptor tyrosine kinase(NRTK)is an important signaling molecule that regulates cell proliferation and migration as the primary driver of intracellular signaling pathway transduction.Targeting NRTK has become the focus and difficulty in developing anti-tumor drugs.Traditional Chinese medicine(TCM),with its characteristics of multi-channel,multi-link,multi-target,and low toxicity,plays a significant advantage in treating adjuvant tumors.So far,it has been found various traditional TCM monomers can inhibit NRTK from playing an anti-tumor role.This review summarized the part of Src,Jak,Abl,Fak families,the prominent members of NRTK in tumor progression,as well as the TCM monomers acting on these members.We aimed to provide a theoretical basis for the anti-tumor therapy targeting NRTK and a reference for the search for TCM monomer inhibitors of NRTK.关键词
中药单体/非受体酪氨酸激酶/肿瘤治疗Key words
Traditional Chinese medicine monomers/Non-receptor tyrosine kinase/Tumor therapy分类
医药卫生引用本文复制引用
胡玉洁,魏兰懿,陈君君,周阳云,杨姣,胡九东,韩永龙..中药单体调控非受体型酪氨酸激酶抗肿瘤的研究进展[J].医药导报,2024,43(1):106-114,9.基金项目
上海市自然科学基金资助项目(20ZR144-2400) （20ZR144-2400）
上海市浦东新区科技发展基金民生科研专项基金资助项目(医疗卫生)(PKJ2020-Y08、PKJ2020-Y11) （医疗卫生）
上海市浦东新区卫健委科技项目卫生行业专项项目(PW2021E-03) （PW2021E-03）
上海市浦东新区科技发展基金民生科研专项基金资助项目(PKJ2023-Y51) （PKJ2023-Y51）
国家自然科学基金资助项目(82003987). （82003987）
