基于数据挖掘对前列腺癌预后有预测价值的差异基因筛选OA
Screening of Differentially Expressed Genes with Predictive Value for Prognosis of Prostate Cancer Based on Data Mining
目的 通过数据挖掘筛选对前列腺癌总生存期(OS)及无疾病生存期(DFS)有预测价值的差异基因.方法 通过挖掘GEPIA2数据库中与前列腺癌OS、DFS有关的基因以及肿瘤差异基因信息,探讨上调基因和下调基因与OS、DFS的关系,最后筛选出对前列腺癌OS及DFS有预测价值的差异基因.结果 共筛选出在前列腺癌差异表达的基因3005个,其中上调基因681个、下调基因2324个.与OS有关的基因497个,从中筛选出差异表达的基因63个,其中上调基因6个,下调基因57个,UBE2SP2、RP11-627G23.1、RPL7P23、TK1的上调和前列腺癌较低的OS有关,而RNA5-8S5和ELOVL2高表达的患者前列腺癌OS高于低表达的患者.与DFS有关的基因499个,从中筛选出差异基因184个,其中上调基因9个,C2、FUCA1、C9orf152表达上调的前列腺癌患者DFS较高,而TK1、CDC20、BIRC5、TOP2A、UBE2SP2、FAM223A高表达与较低的DFS有关,下调基因175个.UBE2SP2和TK1存在正相关,且高表达与较差的OS和DFS均有关.结论 本次共筛选出15个与前列腺癌预后有关的上调基因,可为对前列腺癌OS和DFS有预测价值的基因靶点选择提供一定参考.
Objective o screen the differentially expressed genes with predictive value for overall survival(OS)and disease-free survival(DFS)of prostate cancer by data mining.Methods By mining the information of genes related to OS and DFS of prostate cancer and tumor differentially expressed genes in the GEPIA2 database,the relationship between up-regulated genes and down-regulated genes and OS and DFS was explored.Finally,differentially expressed genes with predictive value for OS and DFS of prostate cancer were screened.Results A total of 3005 differentially expressed genes in prostate cancer were screened,including 681 up-regulated genes and 2324 down-regulated genes.There were 497 genes related to OS,and 63 differentially expressed genes were screened out,including 6 up-regulated genes and 57 down-regulated genes.The up-regulation of UBE2SP2,RP11-627G23.1,RPL7P23 and TK1 was related to the lower OS of prostate cancer,while the OS of prostate cancer in patients with high expression of RNA5-8S5 and ELOVL2 was higher than that in patients with low expression.There were 499 genes related to DFS,and 184 differentially expressed genes were screened out,including 9 up-regulated genes.The DFS of prostate cancer patients with up-regulated expression of C2,FUCA1 and C9orf152 was higher,while the high expression of TK1,CDC20,BIRC5,TOP2A,UBE2SP2 and FAM223A was related to lower DFS,and 175 genes were down-regulated.There was a positive correlation between UBE2SP2 and TK1,and high expression was associated with poor OS and DFS.Conclusion A total of 15 up-regulated genes related to the prognosis of prostate cancer are screened,which can provide some reference for the selection of gene targets with predictive value for OS and DFS of prostate cancer.
郝晓明;王玉杰
新疆医科大学第一附属医院泌尿外科,新疆 乌鲁木齐 830054
临床医学
前列腺癌预后总生存期差异基因筛选
Prostate cancerPrognosisOverall survivalDifferentially expressed genesScreening
《医学信息》 2024 (001)
16-21 / 6
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