中风与神经疾病杂志2023，Vol.40Issue(12)：1079-1083,5.DOI:10.19845/j.cnki.zfysjjbzz.2023.0233
NMDA受体在偏头痛中作用的研究进展
Research progress on the role of NMDA receptors in migraine
摘要
Abstract
N-methyl-D-aspartate(NMDA)receptors are ionotropic glutamate receptors that are widely expressed in the central nervous system.Through mediating Ca2+ influx for excitatory synaptic transmission,NMDA receptors play an im-portant role in synaptic plasticity,learning,and memory.Migraine is a common primary headache that brings serious life and mental burdens to patients because of frequent attacks.The pathogenesis of migraine is still unclear.Glutamate and NMDA receptors have been demonstrated to be closely related to the occurrence of migraine.This paper reviews progress on the association of NMDA receptors with migraine and the use of NMDA receptor antagonists for the prevention and treat-ment of migraine,aiming to provide a reference for the pathogenesis and drug treatment of migraine.关键词
偏头痛/N-甲基-D-天冬氨酸受体/N-甲基-D-天冬氨酸受体拮抗剂/皮质扩散抑制Key words
Migraine/NMDA receptor/NMDA receptor antagonist/Cortical spreading depression分类
临床医学引用本文复制引用
黄亚楠,林亚可,孙婷婷,潘永惠..NMDA受体在偏头痛中作用的研究进展[J].中风与神经疾病杂志,2023,40(12):1079-1083,5.基金项目
国家自然科学基金项目(82071549) （82071549）
黑龙江省自然科学基金重点项目(ZD2019H006) （ZD2019H006）
黑龙江省教育科学"十三五"规划重点课题(GJB1319086) （GJB1319086）
