中风与神经疾病杂志2023，Vol.40Issue(12)：1108-1113,6.DOI:10.19845/j.cnki.zfysjjbzz.2023.0238
性别差异与颈动脉粥样硬化斑块:基于UPLC-MS技术的代谢组学研究
Gender differences with carotid atherosclerotic plaque:a metabolomic study based on UPLC-MS
摘要
Abstract
Objective The purpose of this study is to explore the differences of urine metabolites in carotid athero-sclerotic plaque patients of different sexes,explore the different pathogenesis of carotid atherosclerotic plaque in men and women,and try to explain the biological differences caused by gender.Methods Urine of 28 men and 14 women with ca-rotid atherosclerotic plaque were collected and analyzed by ultraperformance liquid chromatography mass spectrometry(UPLC-MS).Perform metabolomics data analysis based on the Metaboanalysis website to identify differential metabolites between male and female patients.In order to further understand the function of metabolites,biological function and path-way enrichment analysis were conducted on metabolites.Results There were significant differences in the expression of 34 metabolites in the urine of patients with carotid atherosclerotic plaque of different sexes.The functions of these metabo-lites are mainly enriched in histidine metabolism,β-Alanine metabolism,arginine biosynthesis,pantothenate and coen-zyme A biosynthesis,and glutathione metabolism pathways.Conclusion There are significant differences in urine meta-bolic profiles between male and female patients with carotid atherosclerotic plaque.关键词
颈动脉粥样硬化斑块/代谢组学/男性/女性Key words
Carotid atherosclerotic plaque/Metabolomics/Male/Female分类
医药卫生引用本文复制引用
喻恬,张秋娟,鲁鹤臻,王优,徐保锋,刘锐..性别差异与颈动脉粥样硬化斑块:基于UPLC-MS技术的代谢组学研究[J].中风与神经疾病杂志,2023,40(12):1108-1113,6.基金项目
吉林大学研究生创新基金(202209) （202209）
