中风与神经疾病杂志2023，Vol.40Issue(12)：1114-1118,5.DOI:10.19845/j.cnki.zfysjjbzz.2023.0239
抗SOX-1,GABABR和VGCC抗体阳性的副肿瘤综合征:病例报告与文献回顾
Paraneoplastic neurological syndrome with positive SOX-1,GABABR,and VGCC antibodies:A case report and literature review
摘要
Abstract
Objective Paraneoplastic neurological syndrome is a rare immune-mediated disease induced by un-derlying tumors,and early identification of special subtypes of paraneoplastic syndrome and specific autoantibodies can guide efficient tumor screening,thereby promoting timely antitumor treatment and prolonging survival time.Methods A retrospective analysis was performed for the diagnosis and treatment of a case of paraneoplastic neurological syndrome with multiple clinical phenotypes and multiple autoantibodies who was admittd to Department of Neurology,Weifang People's Hospital,and a systmatical review was performed for related articles.Results The patient presented with unsteady gait and mental and behavioral disorders in the early stage and was initially diagnosed with paraneoplastic cerebellar degeneration and paraneoplastic limbic encephalitis with positive anti-SOX-1 and anti-GABABR antibodies.Due to abnormal electrophysiologi-cal results and positive P/Q-type VGCC antibodies,the patient was considered to have Lambert-Eaton myasthenic syndrome,and all evidence suggested that the patient had occult small cell lung cancer.Finally thoracoscopic biopsy confirmed that lymph node enlargement on PET-CT was in accordance with the pathological changes of small cell lung cancer.The patient received both antitumor treatment and immunotherapy and had a survival time of 19 months.Conclusion The detection of anti-SOX1 antibodies should promote the screening for small cell lung cancer.In patients with paraneoplastic limbic en-cephalitis and paraneoplastic neuromuscular syndromes mediated by cell surface antibodies,immunotherapy should be ini-tiated in parallel with antitumor treatment,and such patients tend to have a good prognosis.关键词
副肿瘤综合征/抗SOX-1抗体/抗GABABR抗体/抗P/Q型VGCC抗体/小细胞肺癌Key words
Paraneoplastic neurological syndrome/Anti-SOX1 antibody/Anti-GABABR antibody/Anti-P/Q-type VGCC antibody/Small cell lung cancer分类
医药卫生引用本文复制引用
周丽,杜晓光,魏荣,单迎颖,王磊,王鹏,刘琦慧,丁砚生..抗SOX-1,GABABR和VGCC抗体阳性的副肿瘤综合征:病例报告与文献回顾[J].中风与神经疾病杂志,2023,40(12):1114-1118,5.基金项目
潍坊市科技发展计划项目(2021YX061) （2021YX061）
