中国当代儿科杂志2024，Vol.26Issue(1)：92-97,6.DOI:10.7499/j.issn.1008-8830.2306157
A族链球菌体内耐受β-内酰胺类药物的机制研究进展
Research progress on the mechanism of β-lactam resistance in group A Streptococci in vivo
摘要
Abstract
β-lactams,including penicillin,have been used for over 80 years in the treatment of group A Streptococcus(GAS)infections.Although β-lactam-resistant GAS strains have not been identified in vitro tests,clinical treatment failures have been reported since the 1950s.The mechanism underlying the clinical failure of β-lactam treatment in GAS infections remains unclear.Previous research has suggested that β-lactam resistance in GAS in vivo is associated with reduced drug susceptibility of strains,bacterial inoculation effects,biofilm formation,the effect of coexisting bacteria,bacterial persistence,and bacterial internalization into host cells.This article reviews the main reports on β-lactam treatment failure in GAS infections and analyzes the possible mechanisms of β-lactam resistance in vivo.The findings aim to contribute to future research and clinical approaches in the field.关键词
A族链球菌/化脓性链球菌/青霉素/β-内酰胺类药物/治疗失败Key words
Group A Streptococcus/Streptococcus pyogenes/Penicillin/β-lactam/Treatment failure引用本文复制引用
郭孟杨,姚开虎..A族链球菌体内耐受β-内酰胺类药物的机制研究进展[J].中国当代儿科杂志,2024,26(1):92-97,6.基金项目
兵团财政科技计划项目南疆重点产业创新发展支撑计划(2021DB020). （2021DB020）
