中国药房2024，Vol.35Issue(1)：90-94,5.DOI:10.6039/j.issn.1001-0408.2024.01.16
实体器官移植受者接受霉酚酸类药物TDM的意愿调查
Investigation of patients'preferences regarding therapeutic drug monitoring of mycophenolic acid in solid organ transplantation
摘要
Abstract
OBJECTIVE To investigate the preferences of patients who underwent solid organ transplantation regarding therapeutic drug monitoring(TDM)of mycophenolic acid(MPA)and explore the factors influencing patients'decision-making process,so as to provide support for the development of individualized medication guidelines for MPA and improvement of clinical decision-making.METHODS The cross-sectional study was used to design the questionnaire on the patients'preferences to accept MPA TDM,and involved patients who underwent solid organ transplantation and received MPA treatment at two tertiary hospitals in Beijing from April 14,2022,to June 27,2022.The Likert 5-level scoring method was used to score the patients'preferences to accept MPA TDM,the influencing factors and their correlation of the patients'preferences to accept MPA TDM were analyzed by Pearson correlation analysis and binary Logistic regression analysis,and the nonparametric test and chi-square test were used to rank and analyze the consistency of the factors affecting patients'preference decision.RESULTS A total of 140 questionnaires were collected,and the effective recovery rate was 77.35%.The average preference score of 140 patients to receive MPA TDM was(4.01±0.65),and the overall preference value was high.There were 116(82.86%)patients agreed or strongly agreed with MPA TDM.Significant differences were observed in preference scores between patients who had previously undergone MPA TDM and those who had never undergone it[(4.30±0.53)scores vs.(3.80±0.65)scores,P＜0.001].Additionally,patients'preference scores were significantly influenced by their understanding level and attention level(P＜0.001).The ranking of factors contributing to decision-making exhibited consistency(P＜0.001).The factors were ranked in descending order of clinical efficacy,safety,comfortability,economy and time cost.CONCLUSIONS The patients who underwent solid organ transplantation hold high preferences towards MPA TDM.The primary factors influencing their decisions are their prior experience,understanding level,and attention level.关键词
霉酚酸类药物/治疗药物监测/患者意愿/实体器官移植/问卷调查Key words
mycophenolic acid/therapeutic drug monitoring/patient's preferences/solid organ transplantation/questionnaire survey分类
医药卫生引用本文复制引用
刘爽,陈鸿圣,郭琦,程吟楚,赵荣生,侯小飞..实体器官移植受者接受霉酚酸类药物TDM的意愿调查[J].中国药房,2024,35(1):90-94,5.基金项目
国家自然科学基金项目(No.72074005) （No.72074005）
