中国实用外科杂志2023，Vol.43Issue(12)：1407-1412,6.DOI:10.19538/j.cjps.issn1005-2208.2023.12.18
白蛋白-胆红素评分对肝细胞癌切除术后早期复发预测价值研究
Predictive value of ALBI score for early recurrence of hepatocellular carcinoma after liver resection
摘要
Abstract
Objective To investigate the risk factors of early recurrence of hepatocellular carcinoma(HCC)after liver re-section,and to evaluate the value of ALBI score in predicting early recurrence of HCC after liver resection.Methods Clinical data of patients diagnosed with HCC combined with hepatectomy in the Department of Hepatopancreatobiliary Surgery,The First Affiliated Hospital of Zhengzhou University from January 2016 to December 2020 were retrospectively collected and divided into two groups according to whether they had recurrence within 2 years after surgery:early recur-rence group(n=63,recurrence within 2 years)and no early recurrence group(n=75,no recurrence within 2 years).The risk factors of early recurrence were analyzed.Kaplan-Meier method and Log-Rank test were used to compare the tumor-free survival rate of patients with different ALBI scores.Results There were significant differences in maximum tumor diam-eter,microvascular invasion,alkaline phosphatase,alpha-fetoprotein and ALBI scores between early recurrence group and non-early recurrence group(P＜0.05).Multivariate Logistic regression analysis showed tumor diameter(OR=2.201,95％CI 1.055-4.594,P=0.036),MVI(OR=2.425,95％CI 1.058-5.562,PP=0.036)and ALBI grade(OR=2.442,95％CI 1.130-5.279,P=0.023)are independent risk factors for early recurrence after HCC resection.There were differences in recur-rence at 6 months,1 year and 2 years after resection in different ALBI groups(P＜0.05).Kaplan-Meier recurrence-free survival curve showed that the recurrence risk in high-grade ALBI group was higher than that in low-grade ALBI group,and the difference was statistical-ly significant(P＜0.05).Conclusion ALBI score has a certain value in predicting early recurrence af-ter HCC resection,and can be used for risk stratification of postoperative recurrence in HCC patients.关键词
肝细胞癌/肝切除术/白蛋白-胆红素评分/早期复发Key words
hepatocellular carcinoma/hepatectomy/ALBI score/early recurrence分类
医药卫生引用本文复制引用
凌帅波,李路豪,刘兆臣,李素新,李林,刘胜炎,党晓卫..白蛋白-胆红素评分对肝细胞癌切除术后早期复发预测价值研究[J].中国实用外科杂志,2023,43(12):1407-1412,6.基金项目
河南省高等学校重点科研项目(No.21A320062) （No.21A320062）
