中国药房2024，Vol.35Issue(1)：124-128,5.DOI:10.6039/j.issn.1001-0408.2024.01.22
中药调控Nrf2/HO-1信号通路干预心肌缺血再灌注损伤的研究进展
Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury
摘要
Abstract
Myocardial ischemia-reperfusion injury(MIRI)is a serious complication of revascularization in patients with myocardial infarction.The nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling pathway plays an important role in the pathological process of MIRI.Currently,research has found that traditional Chinese medicine has a good effect on myocardial injury caused by ischemia-reperfusion.Based on the Nrf2/HO-1 signaling pathway,this article summarizes the action mechanism of traditional Chinese medicine formulas and monomers in intervening with MIRI.It is found that traditional Chinese medicine formulas(Yixin formula,Wenyang tongmai formula,Dingxin formula Ⅰ),monomers such as terpenoids(ginkgolides,astragaloside Ⅳ,ginsenosides),phenols(brazilin,hematoxylin A,resveratrol)and quinones(aloe,emodin)can alleviate MIRI by activating the Nrf2/HO-1 signaling pathway,inhibiting oxidative stress and inflammatory reactions,etc.关键词
中药/心肌缺血再灌注损伤/核转录因子红系2相关因子2/血红素加氧酶1/信号通路Key words
traditional Chinese medicine/myocardial ischemia-reperfusion injury/nuclear factor erythroid 2-related factor 2/heme oxygenase-1/signaling pathway分类
医药卫生引用本文复制引用
贾素霞,徐晓敏,杨慧聪,刘树民..中药调控Nrf2/HO-1信号通路干预心肌缺血再灌注损伤的研究进展[J].中国药房,2024,35(1):124-128,5.基金项目
黑龙江省中医药学会2022-2024年度青年人才托举工程项目(No.黑中学会[2022]85号) （No.黑中学会[2022]85号）
