中国实验动物学报2023，Vol.31Issue(11)：1431-1438,8.DOI:10.3969/j.issn.1005-4847.2023.11.007
2型糖尿病及其微血管并发症动物模型生化指标特征分析
Biochemical characteristics of type 2 diabetes mellitus and its microvascular complications in animal models
摘要
Abstract
Objective By summarizing experimental data of animal models of type 2 diabetes mellitus(T2DM)and its microvascular complications in rats and mice as animal models,the biochemical indexes were analyzed in order to provide theoretical reference for future experiments.Methods The main topics of"type 2 diabetes""diabetic nephropathy""diabetic foot"and"diabetic retinopathy"were searched on China National Knowledge Infrastructure and PubMed databases to screen out the journal literatures related to T2DM and microvascular complications in clinical and animal experiments published from October 31,2019 to October 31,2022.The subjects,disease types,detection indicators and other contents recorded in the literature were sorted out and summarized,and a database was established for statistical analysis.Results A total of 510 literatures were selected,among which fasting blood glucose was the most frequently used biochemical index in T2DM experiment,urine protein level was the most frequently used biochemical index in diabetic nephropathy experiment,and serum inflammatory factors were the most frequently used biochemical index in diabetic foot and diabetic retinopathy experiment.Conclusions By analyzing the application frequency of biochemical indicators in T2DM and its microvascular complications,this study can provide an important reference for clinical diagnosis and treatment of the disease and the development of animal experiments.关键词
2型糖尿病/微血管并发症/动物模型/生化指标Key words
type 2 diabetes mellitus/microvascular complications/animal model/biochemical index分类
生物科学引用本文复制引用
代浩然,王跃,王旭,朴成玉,刘静,吴修红..2型糖尿病及其微血管并发症动物模型生化指标特征分析[J].中国实验动物学报,2023,31(11):1431-1438,8.基金项目
国家自然科学基金项目(82174274),黑龙江省中医药管理局(zyw2022-076).Funded by National Natural Science Foundation of China(82174274),Heilongjiang Province Traditional Chinese Medicine Classic Popularization Research Project(zyw2022-076). （82174274）
