中国实验动物学报2023，Vol.31Issue(11)：1439-1446,8.DOI:10.3969/j.issn.1005-4847.2023.11.008
基于数据挖掘的青光眼动物模型的应用特点分析
Application and characteristics of a glaucoma animal model based on data mining
摘要
Abstract
Objective To study the application of an animal model of glaucoma and provide a reference for improved animal experimental method and models.Methods We searched the CNI and PubMed databases using the terms"glaucoma"and"animal models"to identify studies related to animal models of glaucoma from 2012 to 2022.The study species,sex,modeling method,and detection indexes were summarized,and a database was established for statistical analysis.Results In total,400 articles conforming to the criteria were selected.Most of the experimental animals were C57BL/6J mice and most of them were male.The most common modeling method were anterior chamber injection-induced,transgenic,and laser photocoagulation-induced models.The most frequent detection indicators included intraocular pressure measurement,histopathology,Western Blot analysis,and immunohistochemistry.Conclusions Numerous method have been used to construct glaucoma animal models,but the intervention of related traditional Chinese medicine factors is less.It is suggested to increase the glaucoma animal model combined with disease and syndrome.This study evaluated different animal models of glaucoma by data mining to provide references for the construction of animal models with high modelling-success rates,good reproducibility,and high clinical coincidence,as well as providing ideas for model improvement.关键词
青光眼动物模型/数据挖掘/造模要素/应用分析Key words
animal model of glaucoma/data mining/moulding element/application analysis分类
生物科学引用本文复制引用
袁晞钒,付琼怡,苗明三..基于数据挖掘的青光眼动物模型的应用特点分析[J].中国实验动物学报,2023,31(11):1439-1446,8.基金项目
国家自然科学基金(80274038),岐黄学者(国中医药人教函 2022-6),河南省重大公益专项(201300310100).Funded by National Natural Science Foundation of China(80274038),Scholar Qihuang(Chinese Medicine Education Letter 2022-6),Major Public Welfare Project of Henan Province(201300310100). （80274038）
