中国实验动物学报2023，Vol.31Issue(11)：1447-1461,15.DOI:10.3969/j.issn.1005-4847.2023.11.009
紫杉醇诱导的神经病理性疼痛大鼠和小鼠动物模型研究及其在中医药方面应用进展
Animal models of paclitaxel-induced neuropathic pain in rats and mice and their application in traditional Chinese medicine
摘要
Abstract
Traditional Chinese medicines have demonstrated clinical efficacy in preventing and treating chemotherapy-induced peripheral neuropathic pain(CIPNP).However,their specific clinical application and mechanism of action require further in-depth study and exploration.There is thus a need to develop more accurate and clinically relevant animal models that reflect the occurrence and development of human diseases as a tool for research.This review provides an in-depth analysis and discussion of the recent establishment and detection criteria of existing rat and mouse animal models of paclitaxel-induced peripheral neuropathic pain.We also evaluate and explain the application of these models for the prevention and treatment of CIPNP in traditional Chinese medicine,thus providing a theoretical basis and reference for future experimental and mechanistic research on the subject.This research will benefit clinical practice and promotion,offering valuable insights into preventing and treating CIPNP using traditional Chinese medicines.关键词
紫杉醇/化疗/周围神经病理性疼痛/动物模型/中医药防治Key words
paclitaxel/chemotherapy/peripheral neuropathic pain/animal model/traditional Chinese medicine prevention and treatment分类
生物科学引用本文复制引用
于俊,李明珠,朴浩哲,崔颖,张立德,金圣博,王建波..紫杉醇诱导的神经病理性疼痛大鼠和小鼠动物模型研究及其在中医药方面应用进展[J].中国实验动物学报,2023,31(11):1447-1461,15.基金项目
国家自然科学基金(82104838),辽宁省自然科学基金(2022-BS-059).Funded by National Natural Science Foundation of China(82104838),Provincial Natural Science Foundation of Liaoning(2020-BS-059). （82104838）
