中国医学科学院学报2023，Vol.45Issue(6)：967-972,6.DOI:10.3881/j.issn.1000-503X.15325
异基因嵌合抗原受体T细胞技术的研究进展
Advances in Allogeneic Chimeric Antigen Receptor T Cells
摘要
Abstract
Autologous chimeric antigen receptor(CAR)T-cell therapy has improved the prognosis of hematological malignancies.Nevertheless,allogeneic CAR-T cells have potential advantages over the autologous approach available on the market.However,allogeneic CAR-T cells may cause life-threatening graft-versus-host disease(GVHD)or be rapidly eliminated by the host immune system.In this review,we analyze the different sources of T cells for optimal allogeneic CAR-T cell therapy,describe the different approaches,and introduce the gene editing measures to produce allogeneic CAR-T cells with limited potential for GVHD and improved anti-tumor effect.关键词
异基因/嵌合抗原受体T细胞/进展Key words
allogeneic/chimeric antigen receptor T cell/advance分类
医药卫生引用本文复制引用
赵茜,李锋..异基因嵌合抗原受体T细胞技术的研究进展[J].中国医学科学院学报,2023,45(6):967-972,6.基金项目
国家自然科学基金青年项目(81800126)和东部战区总医院院管课题(YYMS2021037) （81800126）
