中国实验动物学报2023，Vol.31Issue(11)：1479-1484,6.DOI:10.3969/j.issn.1005-4847.2023.11.012
NK细胞及其免疫疗法在肿瘤免疫治疗中的应用
Application of NK cells and their immunotherapy in tumor immunotherapy
摘要
Abstract
Natural killer(NK)cells as intrinsic immune cells kill tumor cells without the need for pre-stimulation by tumor antigens.Therefore,NK cell based immunotherapy has unique advantages and has made significant progress in tumor treatment.In this article,we review the development,classification,and mechanism of NK cells as well as the applications of NK cell based immunotherapies,including immune checkpoint inhibitors,adoptive cell therapy,and NK cell adapters in tumor immunity.Thus,we elucidate the principle,current status,and developmental trend of NK cell-based anti-tumor immunotherapies to provide ideas for their development and application in the field of tumor immunotherapy.关键词
自然杀伤细胞/免疫疗法/肿瘤免疫/临床治疗Key words
natural killer cells/immunotherapy/tumor immunity/clinical treatment分类
生物科学引用本文复制引用
王赛飞,荀敬,武雪亮,张晖,张琦,张大鹏..NK细胞及其免疫疗法在肿瘤免疫治疗中的应用[J].中国实验动物学报,2023,31(11):1479-1484,6.基金项目
天津市自然科学基金重点项目(20JCZDJC00780),天津市自然科学基金重点项目(21JCZDJC00450),天津市中医药重点领域科研项目(2023008),天津市中医药管理局中医中西医结合项目(2021008,2021043).Funded by Key Program of Natural Science Foundation of Tianjin(20JCZDJC00780),Key Program of Natural Science Foundation of Tianjin(21JCZDJC00450),Tianjin Key Research Project of Traditional Chinese Medicine(2023008),Traditional Chinese Medicine and Combined Traditional Chinese Medicine and Western Medicine Program of the Tianjin Municipal Administration of Traditional Chinese Medicine(2021008,2021043). （20JCZDJC00780）
