中国医药科学2023，Vol.13Issue(23)：52-55,146,5.DOI:10.20116/j.issn2095-0616.2023.23.12
Egl-9家族缺氧诱导因子1的研究进展及与肺癌的关系
Research progress of Egl-9 family hypoxia inducible factor 1 and its relationship with lung cancer
摘要
Abstract
Egl-9 family hypoxia inducible factor 1(EGLN1),an oxygen sensitive factor,is an important oxygen sensor in mammals,which encodes PHD2 in the prolyl hydroxylase domain(PHD).Hydroxylation of hypoxia inducible factor-1α(HIF-1α)promotes the degradation of HIF-1α proteasome,thus affecting erythropoiesis,glycolysis and iron metabolism.EGLN1 is related to polycythemia,heart diseases,brain metabolic diseases and other diseases,and can also affect the occurrence and development of tumors by inhibiting tumor angiogenesis and interacting with tumor suppressor genes and other ways,but it has different functions in different cancers.Lung cancer,as the most common and most malignant tumor,is also receiving increasing attention in its relationship with EGLN1,but its specific mechanism is not completely clear.This paper systematically expounds the structure,mechanism of action,expression in tumor and significance of EGLN1 as well as its relationship with lung cancer,aiming at further discussing the research progress of EGLN1 gene and its relationship with lung cancer,thus providing new ideas for targeted therapy of lung cancer.关键词
Egl-9家族缺氧诱导因子1/缺氧诱导因子-1α/脯氨酰羟化酶结构域2/肺癌Key words
Egl-9 family hypoxia inducible factor 1/Hypoxia inducible factor-1α/Prolyl hydroxylase domain 2/Lung cancer分类
医药卫生引用本文复制引用
白巧会,艾丽,蒋绒,李永霞..Egl-9家族缺氧诱导因子1的研究进展及与肺癌的关系[J].中国医药科学,2023,13(23):52-55,146,5.基金项目
昆明医科大学第二附属医院院内科技计划项目(2021yk014). （2021yk014）
