中国医学创新2023，Vol.20Issue(36)：1-5,5.DOI:10.3969/j.issn.1674-4985.2023.36.001
反比例机械通气联合CPAP治疗新生儿胎粪吸入综合征合并Ⅱ型呼吸衰竭的临床效果
Clinical Effect of Inverse Ratio Ventilation Combined with CPAP in the Treatment of Neonatal Meconium Aspiration Syndrome Complicated with Type Ⅱ Respiratory Failure
摘要
Abstract
Objective:To explore the effect of inverse ratio ventilation(IRV)combined with continuous positive airway pressure(CPAP)in the treatment of neonatal meconium aspiration syndrome(MAS)complicated with type Ⅱ respiratory failure.Method:A total of 80 children with MAS complicated with type Ⅱ respiratory failure admitted to Jiangxi Maternal and Child Health Hospital from June 2019 to June 2021 were selected and divided into observation group(n=40)and control group(n=40)according to random number table method.Children in the control group received CPAP,and children in the observation group received IRV combined with CPAP.Blood gas analysis indexes[pH value,arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)]and the levels of interleukin-6(IL-6)and interleukin-10(IL-10)of both groups before treatment and 48 h after treatment were recorded,and the breathing support time,short breath release time,total hospital stay and complication rate of both groups were recorded.Result:After treatment,PaO2 and pH value in both groups were significantly increased compared with those before treatment,and those in the observation group were higher than those in the control group,PaCO2 in both groups were significantly decreased compared with those before treatment,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).The breathing support time,short breath release time,total hospital stay in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).After treatment,IL-6 in both groups were decreased significantly compared with those before treatment,and that in the observation group was lower than in the control group,while IL-10 in both groups were significantly increased compared with those before treatment,and that in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).The complication rate of observation group was 7.50%,which was significantly lower than 25.00%of control group(P<0.05).Conclusion:IRV combined with CPAP in the treatment of neonatal MAS complicated with type Ⅱ respiratory failure can effectively improve the oxygenation of the children,promote the relief of short breath symptom,shorten the length of hospital stay,and reduce the incidence of complications.关键词
反比例机械通气/持续气道正压通气/新生儿/胎粪吸入综合征/Ⅱ型呼吸衰竭/血气分析Key words
Inverse ratio ventilation/Continuous positive airway pressure/Newborn/Meconium aspiration syndrome/Type Ⅱ respiratory failure/Blood gas analysis引用本文复制引用
胡向文,高菊梅,唐文燕..反比例机械通气联合CPAP治疗新生儿胎粪吸入综合征合并Ⅱ型呼吸衰竭的临床效果[J].中国医学创新,2023,20(36):1-5,5.基金项目
江西省卫生计生委科技计划项目(20201096) （20201096）
