中国比较医学杂志2023，Vol.33Issue(12)：75-85,11.DOI:10.3969/j.issn.1671-7856.2023.12.012
血管性痴呆动物模型的研究概述
A review of animal models of vascular dementia
摘要
Abstract
Vascular dementia(VD)is caused by cerebrovascular diseases,either hemorrhage or ischemic damage in the brain,with ischemia being the most common.In recent years,increasing efforts have been made to study the etiology,pathogenesis,and prevention of VD.The establishment of appropriate animal models to study the mechanism of VD and explore the efficacy of VD treatments has become an important issue in this research field.On the basis of conventional method,such as bilateral occlusion of common carotid arteries(2VO)and four-vessel occlusion,researchers have modified these method to improve stability with better reflection of the clinical manifestations of VD.This review summarizes these modified method and discusses possible cellular and molecular mechanisms and their advantages and disadvantages.关键词
血管性痴呆/动物模型/研究概述Key words
vascular dementia/animal model/research review分类
医药卫生引用本文复制引用
宋元毓,陈英华,李俊峰,孙玮..血管性痴呆动物模型的研究概述[J].中国比较医学杂志,2023,33(12):75-85,11.基金项目
国家自然科学基金(82074530) （82074530）
黑龙江省自然科学基金(ZD2021H007). （ZD2021H007）
