中国比较医学杂志2023，Vol.33Issue(12)：86-92,7.DOI:10.3969/j.issn.1671-7856.2023.12.013
单细胞转录组技术在神经退行性疾病上的应用研究进展
Application research progress of single cell RNA-sequencing technology in neurodegenerative diseases
摘要
Abstract
Neurodegenerative diseases(NDs)are closely related to the central nervous system and characterized by morphological abnormalities and progressive loss of function in specific neuron groups.The main NDs include Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,multiple sclerosis and Huntington's disease.However,no direct therapies for NDs exist.In recent years,single cell RNA-sequencing(scRNA-seq)has been widely used in various NDs.The pathogenesis of NDs is closely related to morphology of immune cells,and the pathogenesis mainly involves mitochondrial function,glucose metabolism,inflammation,and synaptic transmission.Induced pluripotent stem cells are a potential therapy for NDs.Ultimately,we review the application of scRNA-seq to various NDs and provide a reference for prevention and treatment of NDs.关键词
神经退行性疾病/单细胞转录组技术/中枢神经系统/发病机制Key words
neurodegenerative diseases/single cell RNA-sequencing/central nervous system/pathogenesis分类
医药卫生引用本文复制引用
邬建飞,刘宇,魏岱旭,蒲建林,蔡端芳,王丙龙..单细胞转录组技术在神经退行性疾病上的应用研究进展[J].中国比较医学杂志,2023,33(12):86-92,7.基金项目
国家自然科学基金(31900950) （31900950）
自贡市卫生健康委员会科研课题(22yb001,22yb002) （22yb001,22yb002）
自贡市科技计划项目(2023YKY11). （2023YKY11）
