中国比较医学杂志2023，Vol.33Issue(12)：93-96,4.DOI:10.3969/j.issn.1671-7856.2023.12.014
饮食诱导非酒精性脂肪性肝病动物模型的研究进展
Advances in animal models of diet-induced non-alcoholic fatty liver disease
摘要
Abstract
The establishment of effective animal models is crucial for disease research.Dietary induction is a common method to establish animal models of non-alcoholic fatty liver disease(NAFLD).The common animal models of diet-induced NAFLD mainly include high fat and sugar,high fat and cholesterol,and choline-deficient diet-induced models.Because of the various nutrients ingested in different modeling method,pathological characteristics of the liver,such as fatty deformation,inflammation,and fibrosis,are different.Additionally,animal models vary in terms of disease progression,disease severity,and applicable studies.This study analyzed and compared the common animal models of NAFLD induced by various diets in terms of modeling method,modeling time,pathological characteristics,applicable research,and related advantages and disadvantages to provide a reference for NAFLD researchers to select animal models.关键词
非酒精性脂肪性肝病/啮齿类动物/动物模型Key words
non-alcoholic fatty liver disease/rodents/animal model分类
医药卫生引用本文复制引用
王佳林,王重阳,李杨,陈贤玮,袁中楠,邹朝霞,邹臣丹..饮食诱导非酒精性脂肪性肝病动物模型的研究进展[J].中国比较医学杂志,2023,33(12):93-96,4.基金项目
国家自然科学基金青年科学基金(81900553). （81900553）
