中国现代医学杂志2023，Vol.33Issue(24)：74-79,6.DOI:10.3969/j.issn.1005-8982.2023.24.013
强直性脊柱炎患者外周血不同类型单核细胞极化与病情严重程度的关系
The relationship between the polarization of monocytes in peripheral blood and the disease severity of AS patients
摘要
Abstract
Objective To investigate the relationship between different types of monocyte polarization in peripheral blood and the disease severity of patients with ankylosing spondylitis(AS).Methods From January 2020 to December 2021,a total of 71 AS patients(AS group)and 80 age-and sex-matched volunteers undergoing health checkup(control group)in Shenzhen Pingle Orthopedics and Traumatology Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine were selected.Flow cytometry was performed to detect the proportions of CD36+,CD206+,and CD68+monocytes,and the correlations between distinct subsets of monocytes and the disease activity indexes were analyzed.The changes of the different types of monocytes before and after treatment were determined.Results The levels of CRP,ESR,IgG,IgM,IgA,TNF-α,and IL-6 in the AS group were significantly higher than those in the control group(P＜0.05).Compared with the control group,the proportions of CD36+and CD206+cells in peripheral blood were significantly lower but the proportion of CD68+cells in peripheral blood was higher in the AS group(P＜0.05).The proportions of CD36+and CD206+cells were negatively correlated with BASDAI scores and BASFI scores(P＜0.05),and the proportion of CD68+cells was positively correlated with BASDAI scores and BASFI scores(P＜0.05).The levels of CRP,ESR,IgG,IgM,IgA,TNF-α and IL-6 after the treatment were significantly lower than those before the treatment in AS patients(P＜0.05).The proportions of CD36+and CD206+cells after the treatment were increased compared with those before the treatment(P＜0.05),while the proportion of CD68+cells,BASDAI scores and BASFI scores after the treatment were decreased compared with those before the treatment in AS patients(P＜0.05).Conclusions The decreased proportions of CD36+and CD206+monocytes and the increased proportion of CD68+monocytes in the peripheral blood of AS patients are related to the severity of the disease.关键词
强直性脊柱炎/单核细胞/脊柱结构破坏指数/炎症指标Key words
ankylosing spondylitis/monocyte/index reflecting the structural damage in the spine/inflammatory marker分类
医药卫生引用本文复制引用
于翱瑞,张芸,曹亚飞,林文平,高坤,张少群,李伟,覃国忠,霍青云,曾凡宇..强直性脊柱炎患者外周血不同类型单核细胞极化与病情严重程度的关系[J].中国现代医学杂志,2023,33(24):74-79,6.基金项目
广东省自然科学基金面上项目(No:2021A1515010722) （No:2021A1515010722）
广东省中医药局科研项目(No:20221355) （No:20221355）
深圳市科技计划项目(No:JCYJ20210324111205015) （No:JCYJ20210324111205015）
