中国比较医学杂志2023，Vol.33Issue(12)：97-103,7.DOI:10.3969/j.issn.1671-7856.2023.12.015
自噬在系统性硬化症发病机制中作用的研究进展
Research progress on the role of autophagy in the pathogenesis of systemic sclerosis
摘要
Abstract
Systemic sclerosis(SSc)is an autoimmune disease characterized by vascular lesions and skin fibrosis,which causes structural and functional damage to multiple organs.The pathogenesis of SSc is complex and may be related to genetic and environmental factors as well as abnormal immune mechanisms.Autophagy is an evolutionarily conserved process of self-degradation in the body and participates in the pathogenesis of autoimmune diseases through various pathways.This article reviews the research progress on the role of autophagy in the angiopathy and fibrosis of SSc by regulating immune cells and mediating signaling pathways.关键词
自噬/系统性硬化症/血管病变/纤维化/信号通路Key words
autophagy/systemic sclerosis/angiopathy/fibrosis/signaling pathway分类
医药卫生引用本文复制引用
李鑫,孙晓林,王永福..自噬在系统性硬化症发病机制中作用的研究进展[J].中国比较医学杂志,2023,33(12):97-103,7.基金项目
国家自然科学基金(81860294) （81860294）
内蒙古自治区自然科学基金(2019MS08055,2021MS08045) （2019MS08055,2021MS08045）
内蒙古自治区科技计划项目(201802089,2019GG052). （201802089,2019GG052）
