中国比较医学杂志2023，Vol.33Issue(12)：104-111,8.DOI:10.3969/j.issn.1671-7856.2023.12.016
基于表观遗传学调控的中医药治疗中风研究进展
Research progress of traditional Chinese medicine for stroke on the basis of epigenetic regulation
摘要
Abstract
Epigenetics,a branch of molecular biology,plays a pivotal role in the pathological progression of ischemic stroke.Epigenetic modifications are intricately involved in the complex and dynamic processes that regulate gene expression,cellular injury response,motor function,and cognitive ability following stroke.This provides an effective framework for elucidating the targets and mechanisms of action underlying traditional Chinese medicine's treatment of ischemic stroke.Currently,the etiology and pathogenesis of ischemic stroke remain incompletely understood,with modern medical treatments still lacking sufficient efficacy.Traditional Chinese medicine possesses a unique advantage in treating ischemic stroke through its multi-level and multi-target comprehensive regulation.Recent studies have discovered that traditional Chinese medicine can participate in regulating abnormal epigenetic modifications during stroke treatment.This article primarily focuses on the theoretical foundation of traditional Chinese medicine for strokes by exploring its application in DNA methylation,non-coding RNA,histone modification research as well as explaining the epigenetic effects it exerts when treating strokes.The aim is to provide insights for future research and development of traditional Chinese medicine for cerebral ischemia.关键词
表观遗传学/中风/中医药/DNA甲基化/非编码RNA/组蛋白修饰Key words
epigenetics/stroke/traditional Chinese medicine/DNA methylation/non-coding RNA/histone modification分类
医药卫生引用本文复制引用
付雪琴,兰瑞,张勇,王漫漫,邹旭欢,王玮玮..基于表观遗传学调控的中医药治疗中风研究进展[J].中国比较医学杂志,2023,33(12):104-111,8.基金项目
国家自然科学基金(81973618,81503422) （81973618,81503422）
河南省自然科学基金(202300410399). （202300410399）
