中国比较医学杂志2023，Vol.33Issue(12)：112-117,6.DOI:10.3969/j.issn.1671-7856.2023.12.017
HIF-1α信号通路在离体器官冷保存中的保护作用
Protective effects of the HIF-1α pathway on cold storage of isolated organs
摘要
Abstract
Organ transplantation is the main treatment for organ failure.Functional protection of donor organs during ex vivo transportation is critical for the success of organ transplantation.How to protect the functions of donor organs during in vitro transportation is an important issue in the field of organ transplantation research.In a hypoxic environment,transcriptional activity of a series of genes in cells is activated.These genes are mainly involved in angiogenesis,iron metabolism,glucose metabolism,and cell proliferation/survival.In aerobic organisms,hypoxia-inducible factor-1α(HIF-1α)is involved in the regulation of the expression of various genes to maintain homeostasis of tissues and cells under hypoxic conditions,thereby adapting to the hypoxia.Many studies have shown that the HIF-1α pathway plays an important role in protecting isolated organs from cold ischemic injury during cold storage.HIF-1α has been a hot topic in research on the protective mechanism of cold ischemic injury of isolated organs.Regulating the HIF-1α-related signaling pathway is expected to be a new strategy to maintain organ functions during cold storage of isolated organs.关键词
缺氧诱导因子1α/冷保存/器官移植/能量代谢/氧化应激Key words
hypoxia-inducible factor 1α/cold storage/organ transplantation/metabolism/oxidative stress分类
医药卫生引用本文复制引用
王智洋,郑斯阳,朱亮..HIF-1α信号通路在离体器官冷保存中的保护作用[J].中国比较医学杂志,2023,33(12):112-117,6.基金项目
辽宁省教育厅重点攻关科研项目(LZ2020002) （LZ2020002）
2023 辽宁省应用基础研究计划(2023JH2/1668150732551) （2023JH2/1668150732551）
国家重点实验室开放基金(BYSYSZKF2022003). （BYSYSZKF2022003）
