中国医学创新2023，Vol.20Issue(36)：22-25,4.DOI:10.3969/j.issn.1674-4985.2023.36.006
长效胰岛素联合二甲双胍、利拉鲁肽对肥胖2型糖尿病患者血糖水平、腹围的影响
Effects of Long-acting Insulin Combined with Metformin and Liraglutide on Blood Glucose Level and Abdomen Circumference in Obesity Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To analyze the effects of long-acting insulin combined with Metformin and Liraglutide on blood glucose level and abdomen circumference in obesity patients with type 2 diabetes mellitus(T2DM).Method:A total of 80 obesity patients with T2DM admitted to Ji'an Central Hospital from April 2022 to March 2023 were selected as the study objects,and were divided into control group[n=40,treated with Metformin combined with Mixed Protamine Human Insulin Injection(50R)]and observation group[n=40,treated with Metformin,long-acting insulin(Insulin Glargine)and Liraglutide]according to random number table method.Blood glucose level,abdomen circumference,incidence of hypoglycemia and the rate of blood glucose control up to the standard were compared between the two groups.Result:After treatment,the levels of glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2 h PG)in both groups were significantly lower than those before treatment,and the levels of HbA1c,FPG and 2 h PG in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).After treatment,abdomen circumference of observation group was significantly lower than that of control group,the difference was statistically significant(P<0.05).During treatment,there were 2 cases of hypoglycemia in the observation group and 8 cases of hypoglycemia in the control group.The incidence of hypoglycemia in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The rate of blood glucose control up to the standard of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Long-acting insulin combined with Metformin and Liraglutide has a significant effect in the treatment of obesity patients with T2DM,which can lower blood glucose level,reduce abdomen circumference,and the incidence of hypoglycemia is low.关键词
2型糖尿病/预混胰岛素/长效胰岛素/利拉鲁肽/血糖/腹围/低血糖Key words
Type 2 diabetes mellitus/Premixed insulin/Long-acting insulin/Liraglutide/Blood glucose/Abdomen circumference/Hypoglycemia引用本文复制引用
王梅丽,周小智,符金香,陈雨,郭剑平..长效胰岛素联合二甲双胍、利拉鲁肽对肥胖2型糖尿病患者血糖水平、腹围的影响[J].中国医学创新,2023,20(36):22-25,4.基金项目
吉安市科技计划项目(20222-026643) （20222-026643）
