中国药业2023，Vol.32Issue(23)：72-75,4.DOI:10.3969/j.issn.1006-4931.2023.23.015
基于信息熵赋权法的L9(34)正交试验优选治痤方水提工艺
Optimization of Water Extraction Process of Zhicuo Formula by the L9(34)Orthogonal Test Based on Information Entropy Weighting Method
摘要
Abstract
Objective To optimize the water extraction process of Zhicuo Formula.Methods The extraction times,amount of water addition,and extraction time were taken as investigation factors,the weight coefficients of baicalin,salvianolic acid B contents,and extract yield rate were determined by the information entropy weighting method,and the water extraction technology of Zhicuo Formula was optimized by the L9(34)orthogonal test.Results The information entropies of the content and extract yield of baicalin and salvianolic acid B were 0.975 1,0.980 2,and 0.981 0 with the weight coefficients of 0.390 9,0.310 8,and 0.298 3,respectively.The optimal extraction process was as follows:the decoction pieces were added 10 times the amount of water and extracted 3 times for 1.5 h each time.The validation test results showed that the average contents of baicalin and salvianolic acid B were 3.32 mg/mL and 3.24 mg/mL,respectively,the average extract yield was 28.42％,and the average comprehensive score was 0.994 5.Conclusion The optimal water extraction technology of Zhicuo Formula is stable and reliable,which can provide a reference for the extraction process and quality research of Zhicuo Formula.关键词
治痤方/信息熵赋权法/L9(34)正交试验/黄芩苷/丹酚酸B/水提工艺Key words
Zhicuo Formula/information entropy weighting method/L9,(34)orthogonal test/baicalin/salvianolic acid B/extraction technology分类
医药卫生引用本文复制引用
过其玲,韩晓珂..基于信息熵赋权法的L9(34)正交试验优选治痤方水提工艺[J].中国药业,2023,32(23):72-75,4.基金项目
安徽省芜湖市卫生健康委员会2021年华佗计划高层次人才分层培养项目[芜卫组[2021]134号]. （）
