中国中医药图书情报杂志2024，Vol.48Issue(1)：56-62,7.DOI:10.3969/j.issn.2095-5707.202301072
基于网络药理学和分子对接探讨壮骨强筋片治疗老年性骨质疏松症的作用机制
Exploration on the Mechanism of Zhuanggu Qiangjin Tablets in the Treatment of Senile Osteoporosis Based on Network Pharmacology and Molecular Docking Technology
摘要
Abstract
Objective To explore the effective components and mechanism of Zhuanggu Qiangjin Tablets in the treatment of senile osteoporosis(SOP)by means of network pharmacology and molecular docking technology.Methods The active components and targets of Zhuanggu Qiangjin Tablets were screened by TCMSP,HERB,PubChem,SwissTargetPrediction and UniProt database;the related targets of SOP were obtained from DisGeNet,GeneCards and OMIM databases.Cytoscape 3.8.0 was used to construct the"disease-drug-component-intersection target"network.PPI network was constructed using STRING and Cytoscape 3.8.0.After that,R 4.2.0 was used for GO functional enrichment analysis and KEGG pathway enrichment analysis.Finally,the core active components with high moderate value was molecule-docked with the core targets.Results A total of 270 Zhuanggu Qiangjin Tablets related targets were obtained,433 SOP related targets and 61 drug SOP intersection targets were obtained;the core components primarily included quercetin,luteolin,and kaempferol,while the core targets involved TNF,IL6,AKT1,and VEGFA.GO biological processes mainly encompassed oxidative stress response,reproductive structure development,and reproductive system development.The enriched KEGG pathways were primarily associated with AGE-RAGE signaling pathway in diabetic complications,lipid and atherosclerosis,and fluid shear stress and atherosclerosis.Conclusion Zhuanggu Qiangjin Tablets may exert therapeutic effects on SOP by acting on targets such as TNF,IL6,AKT1,and VEGFA,thereby regulating immune response and cellular metabolism.关键词
壮骨强筋片/老年性骨质疏松症/网络药理学/分子对接Key words
Zhuanggu Qiangjin Tablets/senile osteoporosis/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
邬裕,周泽霖,欧阳帅,陈松海,叶林强,张志刚,王志强,卢国樑..基于网络药理学和分子对接探讨壮骨强筋片治疗老年性骨质疏松症的作用机制[J].中国中医药图书情报杂志,2024,48(1):56-62,7.基金项目
广东省东莞市名中医药专家传承工作室建设项目(2019年) （2019年）
