中国医学创新2023，Vol.20Issue(36)：64-69,6.DOI:10.3969/j.issn.1674-4985.2023.36.016
雾化吸入布地奈德联合肺泡灌洗治疗重症肺炎效果及对炎症因子水平的影响
Effectiveness of Nebulized Inhaled Budesonide Combined with Alveolar Lavage in the Treatment of Severe Pneumonia and the Effect on the Levels of Inflammatory Factors
摘要
Abstract
Objective:To investigate the effect of nebulized inhalation Budesonide combined with alveolar lavage in the treatment of severe pneumonia.Method:A total of ninety patients with severe pneumonia treated in Suzhou Municipal Hospital from December 2020 to December 2022 were selected,and divided into in the control group(alveolar lavage)and the observation group(combined nebulized inhalation budesonide)by random number table method,with 45 cases in each group.The treatment effects(time to fever reduction,time to disappearance of cough,time to disappearance of pulmonary rales,hospitalization time),respiratory mechanics indexes[dynamic compliance(Cdyn),airway resistance(Raw),work of breathing(WOB)],pulmonary function indexes[first second expiratory volume(FEV1),maximum ventilation(MVV),peak expiratory flow(PEF)],stress levels[malondialdehyde(MDA),lipid peroxide(LPO),superoxide dismutase(SOD)],inflammatory response mediator levels[macrophage inflammatory response protein-1α(MIP-1α),platelet-activating factor(PAF),soluble myeloid trigger receptor-1(sTREM-1),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor(TNF-α)]of two groups were compared.Result:The time to fever reduction,time to disappearance of cough,time to disappearance of pulmonary rales and hospital stay in the control group were longer than those in the observation group,the differences were statistically significant(P<0.05).Before treatment,the Cdyn,Raw and WOB levels between the two groups were compared,the differences were statistically significant(P>0.05);after treatment,Cdyn levels were increased compared to those before treatment,Raw and WOB were decreased compared to those before treatment in both groups,and the those in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).Before treatment,the differences in FEV1,MVV and PEF levels between the two groups were not significant(P>0.05);after treatment,FEV1,MVV and PEF levels were increased compared to those before treatment in both groups,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,the differences of MDA,LPO and SOD levels between the two groups were not statistically significant(P>0.05);after treatment,SOD levels were increased,LPO and MDA levels were decreased compared to those before treatment in both groups,and SOD in the observation group was higher than that in the control group,and LPO and MDA levels were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of MIP-1α,PAF,sTREM-1,IL-6,IL-8 and TNF-α in the two groups(P>0.05);after treatment,the levels of MIP-1α,PAF,sTREM-1,IL-6,IL-8 and TNF-α were decreased compared to those before treatment in the two groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Treatment of severe pneumonia with nebulized inhalation of Budesonide combined with alveolar lavage can improve the therapeutic effect,improve lung function and respiratory function,reduce oxidative stress,and decrease the levels of inflammatory factors.关键词
雾化吸入/布地奈德/肺泡灌洗/重症肺炎/炎症因子/肺功能/呼吸功能Key words
Nebulized inhalation/Budesonide/Alveolar lavage/Severe pneumonia/Inflammatory factors/Pulmonary function/Respiratory function引用本文复制引用
胡斯明,莫丽亚,石宝玉,李勇..雾化吸入布地奈德联合肺泡灌洗治疗重症肺炎效果及对炎症因子水平的影响[J].中国医学创新,2023,20(36):64-69,6.基金项目
2022 年江苏省卫生健康发展研究中心项目(JSHD2022061) （JSHD2022061）
