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Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity

Yingjie Du Yunfeng Li Xiangting Zhao Yishan Yao Bin Wang Liming Zhang Guyan Wang

中华医学杂志（英文版）2023，Vol.136Issue(24)：2983-2992,10.

中华医学杂志（英文版）2023，Vol.136Issue(24)：2983-2992,10.DOI:10.1097/CM9.0000000000002647

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity

Yingjie Du ¹Yunfeng Li ²Xiangting Zhao ³Yishan Yao ⁴Bin Wang ⁴Liming Zhang ⁴Guyan Wang⁵

作者信息

1. Department of Anesthesiology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China||Beijing Institute of Pharmacology and Toxicology,State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Key Laboratory of Neuropsychopharmacology,Beijing 100850,China
2. Beijing Institute of Pharmacology and Toxicology,State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Key Laboratory of Neuropsychopharmacology,Beijing 100850,China||Beijing Institute of Basic Medical Sciences,Beijing 100850,China
3. Beijing Institute of Pharmacology and Toxicology,State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Key Laboratory of Neuropsychopharmacology,Beijing 100850,China||Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases Basic Medical College of Jiamusi University,Jiamusi,Heilongjiang 154000,China
4. Beijing Institute of Pharmacology and Toxicology,State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Key Laboratory of Neuropsychopharmacology,Beijing 100850,China
5. Department of Anesthesiology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China
折叠

摘要

关键词

Brain-derived neurotrophic factor/Bromodeoxyuridine/Depression/Doublecortin domain proteins/Extinction,psy-chological/Freezing/Hippocampus/Neuronal plasticity/Psilocybin/Stress disorders,post-traumatic

Key words

引用本文复制引用

Yingjie Du,Yunfeng Li,Xiangting Zhao,Yishan Yao,Bin Wang,Liming Zhang,Guyan Wang..Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity[J].中华医学杂志（英文版）,2023,136(24):2983-2992,10.

基金项目

This work was supported by grants from the ST12030-Major Projects(Nos.2021ZD0200900 and 2021ZD0202000),National Natural Science Foundation of China(Nos.81773708,82270411 and 81970344),Beijing Hospitals Authority's Ascent Plan(No.DFL20220203),and Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.ZYLX202103). （Nos.2021ZD0200900 and 2021ZD0202000）

中华医学杂志（英文版）

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