中国医学创新2023，Vol.20Issue(36)：97-101,5.DOI:10.3969/j.issn.1674-4985.2023.36.023
加味五味消毒饮联合常规集束化治疗热毒壅滞型脓毒性心肌病的临床研究
Clinical Study of Supplemented Wuwei Xiaodu Drink Combined with Conventional Bundle Therapy in the Treatment of Patients with Heat-toxin Congestion and Stagnation Type Septic Cardiomyopathy
摘要
Abstract
Objective:To explore the clinical effects of Supplemented Wuwei Xiaodu Drink combined with conventional bundle therapy on patients with heat-toxin congestion and stagnation type septic cardiomyopathy.Method:A total of 90 patients with heat-toxin congestion and stagnation septic cardiomyopathy in the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2021 to December 2022 were collected,randomly divided into 45 cases in the control group and 45 cases in the treatment group.The control group was treated with clinical conventional bundle therapy,and the treatment group was treated with conventional bundle therapy combined with Supplemented Wuwei Xiaodu Drink,consecutively treated for 7 d.The clinical effect was observed,and the levels of N-terminal B-type natriuretic peptide(NT-proBNP),creatine kinase-MB(CK-MB),cardiac troponin I(cTnI),white blood cell(WBC),interleukin-6(IL-6)and procalcitonin(PCT)before and after treatment were compared between the two groups,the acute physiological and chronic health evaluationⅡ(APACHEⅡ)scores were evaluated,and the intensive care unit(ICU)admission time and 28 d mortality were compared.Result:After treatment,the levels of NT-proBNP,CK-MB and cTnI were decreased in both groups compared to those before treatment(P<0.05),and those in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of WBC,IL-6 and PCT were decreased in both groups compared to those before treatment(P<0.05),and those in the treatment group were lower than those in the control group(P<0.05).The differences in the APACHEⅡ score,ICU admission time and 28 d mortality after treatment were statistically significant between the two groups(P<0.05).The total effective rate of treatment in the treatment group was higher than that in the control group(P<0.05).Conclusion:Supplemented Wuwei Xiaodu Drink combined with conventional bundle therapy can improve the clinical effect of patients with septic cardiomyopathy,the inflammatory response can be improved,it has a protective effect on myocardium and plays a certain role in the prognosis of patients with heat-toxin congestion and stagnation type septic cardiomyopathy.关键词
加味五味消毒饮/常规集束化治疗/热毒壅滞型/脓毒性心肌病Key words
Supplemented Wuwei Xiaodu Drink/Conventional bundle therapy/Heat-toxin congestion and stagnation type/Septic cardiomyopathy引用本文复制引用
赵丹,赵永法,万乐,刘涛,杨楠..加味五味消毒饮联合常规集束化治疗热毒壅滞型脓毒性心肌病的临床研究[J].中国医学创新,2023,20(36):97-101,5.基金项目
江西省中医药管理局科技计划项目(2021B022) （2021B022）
