中国医学科学院学报2023，Vol.45Issue(6)：897-901,5.DOI:10.3881/j.issn.1000-503X.15732
老年高血压人群同型半胱氨酸与高尿酸血症的相关性
Association Between Plasma Homocysteine Level and Hyperuricemia in Elderly Patients With Hypertension
摘要
Abstract
Objective To explore the association between plasma homocysteine(Hcy)level and hyper-uricemia(HUA)in the elderly patients with hypertension.Methods From March to August in 2018,9902 hy-pertensive patients ≥ 60 years were routinely tested for blood biochemical indicators in Wuyuan county,Jiangxi province.The patients were assigned into a HUA group and a normal uric acid group.Multivariate Logistic regres-sion was adopted to analyze the relationship between Hcy level and the risk of HUA.Results Compared with the normal uric acid group,the HUA group showed increased incidence of hyperhomocysteinemia(99.9％vs.98.7％,P＜0.001)and elevated Hcy level[16.8(13.8-21.5)μmol/L vs.14.4(12.3-17.7)μmol/L,P＜0.001].The multivariate Logistic regression analysis showed that after adjusting for influencing factors,the risk of HUA in the patients with hyperhomocysteinemia was 2.92 times of that in the patients with a normal Hcy level.The threshold effect analysis showed that the Hcy level was positively correlated with the occurrence of HUA in the case of Hcy＜20 µmol/L(OR=1.05,95％CI=1.04-1.07,P＜0.001).In the case of Hcy ≥ 20 μmol/L,there was no correlation between Hcy level and HUA(OR=1.00,95％CI=0.99-1.00,P=0.055),and the likelihood ratio test showed statistically significant results(P＜0.001).Conclusion The elderly with hyper-tension should pay attention to control the Hcy level,which will be helpful to prevent the occurrence of HUA.关键词
高血压/同型半胱氨酸/高尿酸血症/阈值饱和效应Key words
hypertension/homocysteine/hyperuricemia/threshold saturation effect分类
医药卫生引用本文复制引用
祝玲娟,施建民,王涛,余超,周伟,鲍慧慧,程晓曙..老年高血压人群同型半胱氨酸与高尿酸血症的相关性[J].中国医学科学院学报,2023,45(6):897-901,5.基金项目
"十二五"国家科技支撑计划(2011BAI11B01)、江西省卫生健康委员会科技计划项目(202210495、20203241)和江西省科技创新基地建设项目(20221ZDG02010) （2011BAI11B01）
