肿瘤防治研究2023，Vol.50Issue(12)：1197-1202,6.DOI:10.3971/j.issn.1000-8578.2023.23.0509
SEC61G在口腔鳞癌中的表达及其预后诊断价值
Expression of SEC61G in Oral Squamous Cell Carcinoma and Its Prognostic Value
摘要
Abstract
Objective To analyze the expression of SEC61G in oral squamous cell carcinoma(OSCC)tissues and cell lines and determine its correlations with the clinicopathological features and prognosis of patients with OSCC.Methods The expression of SEC61G in OSCC tissues and its diagnostic and prognostic value were detected in the TCGA database.The expression levels of SEC61G in paraffin-embedded OSCC tissues and adjacent normal tissue specimens of 64 patients with OSCC were detected by immunohistochemistry.The correlation of SEC61G expression in OSCC tissues with the clinicopathological features was analyzed.Kaplan-Meier survival curve analysis showed that the expression of SEC61G correlated with the overall survival time of patients with OSCC.Cox regression analysis was used to analyze prognostic influence factors.Results The expression of SEC61G in OSCC tissues was significantly higher than that in para-carcinoma tissues(P＜0.05),consistent with the results of the TCGA database analysis,and its expression was closely related to N stage and clinical stage(P＜0.05).The overall survival of patients with OSCC in the group with low SEC61G expression was significantly higher than that in the high SEC61G expression group(P＜0.05).N stage and SEC61G expression were the prognostic influence factors for patients with OSCC(P＜0.05).SEC61G expression was an independent predictor of the prognosis of patients with OSCC(P＜0.05,AUC=0.923).Conclusion SEC61G is highly expressed in OSCC tissues and associated with N stage and clinical stage.Its high expression is associated with poor prognosis of patients.It may be a diagnostic biomarker for OSCC.关键词
口腔鳞癌/SEC61G/临床病理特征/预后/诊断Key words
Oral squamous cell carcinoma/SEC61G/Clinicopathological features/Prognosis/Diagnosis分类
医药卫生引用本文复制引用
高瑞,郭磊,彭博,贾骏..SEC61G在口腔鳞癌中的表达及其预后诊断价值[J].肿瘤防治研究,2023,50(12):1197-1202,6.基金项目
Provincial Ministry Co-construction Project from Medical Scientific and Technological Research Program of Henan Province(No.LHGJ20220848)河南省医学科技攻关计划联合共建项目(LHGJ20220848) （No.LHGJ20220848）
