摘要
Abstract
Objective To analyze the clinical characteristics of collagenous gastritis(CG)and provide evidence for the precise diagnosis and treatment of CG.Methods Published case reports and case series were collected from PubMed,CNKI,and Wanfang Med Online with the key words of collagenous gastritis,collage-nous gastroduodenitis,collagenous gastrointestinal diseases,and gastric mucosal nodules.The demographic and clinical information of each case was collected.Results According to the extent of collagen deposition in the di-gestive tract,94 CG cases included in this study were assigned into upper digestive tract(UDT)-CG,total di-gestive tract(TDT)-CG and other groups.The UDT-CG group included 52 cases(57.69％females and 42.31％males)with a median age of 14.50(11.00,25.75)years old.There were 17 cases in the TDT-CG group,including 70.59％females and 29.41％males,with a median age of 15.00(9.50,48.50)years old.The other group contained 25 cases,(64.00％females and 36.00％males)with a median age of 25.00(15.50,59.50)years old.The main clinical manifestations in the UDT-CG group were anemia(59.62％)and diarrhea(17.31％),and those in the TDT-CG group were anemia(29.41％)and diarrhea(94.12％).The nodular appearance of gastric mucosa was observed in 75.00％cases in the UDT-CG group and 35.29％cases in the TDT-CG group.In the initial treatment,symptomatic therapy and hormonal therapy respectively relieved the symptoms in 75.00％(30/40)and 100％(3/3)cases in the UDT-CG group and 57.14％(4/7)and 83.33％(5/6)cases in the TDT-CG group.In the retreatment,symptomatic therapy and hormone therapy respectively achieved the remission rates of 100.00％(3/3)and 88.89％(8/9)in the UDT-CG group and 80.00％(4/5)and 66.67％(2/3)in the TDT-CG group.Conclusions CG,a rare disease of gastric collagen deposition,mainly occurs in young patients,and females are more susceptible than males.The clinical manifestations of CG are nonspecific,and anemia,ab-dominal pain,diarrhea,weight loss,and gastrointestinal bleeding are the common symptoms of CG.Nodular ap-pearance of gastric mucosa is a relatively specific endoscopic feature of CG.There is no standardized treatment for CG.Symptomatic treatment is commonly adopted to improve the quality of life of the patients,and hormones can be added when necessary.关键词
胶原性胃炎/胶原性胃十二指肠炎/胶原性胃肠道疾病/胃黏膜结节Key words
collagenous gastritis/collagenous gastroduodenitis/collagenous gastrointestinal diseases/gastric mucosal nodule分类
医药卫生
