肿瘤防治研究2023，Vol.50Issue(12)：1214-1220,7.DOI:10.3971/j.issn.1000-8578.2023.23.0645
放疗联合普瑞巴林治疗肝癌骨转移神经病理性疼痛的疗效及生存质量评价
Theraputic Effect and Quality of Life Assessment in Patients with Neuropathic Pain Due to Bone Metastasis from Hepatocellular Carcinoma Treated with Radiotherapy and Pregabalin
摘要
Abstract
Objective To evaluate the short-term efficacy and quality of life of primary hepatocellular carcinoma patients after radiotherapy and pregabalin treatment for neuropathic pain with bone metastasis.Methods 32 patients with primary hepatocellular carcinoma bone metastases were treated with radiotherapy combined with pregabalin treatment.Then,we prospectively studied the analgesic efficacy for neuropathic pain and quality of life,used the brief pain inventory and douleur neuropathique 4 questionnaire(DN4)to evaluate pain at baseline,one and two months after radiotherapy,assessed pain response using the international consensus endpoint definition of bone metastasis,and used European Organization for Research and Treatment of Cancer Research and Treatment Quality of Life Questionnaire(EORTC QLQ-C30)and bone metastasis module(QLQ-BM22)for quality of life assessment.Results One and two months after radiotherapy,the average DN4 score of neuropathic pain decreased,and the objective pain relief rates were 62.8％ and 68.6％,respectively.The physical,emotional,social,and role functional scores of EORTC QLQ-C30 functional scale significantly increased in the first month after radiotherapy.Symptom scale of pain(P=0.015),insomnia(P=0.035),and loss of appetite(P=0.022)improved,and fatigue was aggravated(P＜0.05).Two months after radiotherapy,the mean overall health score and all functional scale scores significantly increased than those at baseline.The scores of all symptom scales decreased,except fatigue,constipation,and financial difficulties(P＜0.05).In addition,pain responders showed significant improvement in emotional function(P=0.025)and physical function(P=0.029)in the functional scale and in pain(P=0.014)and fatigue(P=0.035)in the symptom scale.The QLQ-BM22 score showed that the painful sites(P=0.021)and pain characteristics(P=0.04)of the responders significantly improved compared with those of nonresponders two months after radiotherapy.Conclusion Radiotherapy combined with pregabalin can relieve neuropathic pain caused by bone metastasis from primary hepatocellular carcinoma and greatly improve the quality of life,particularly in pain responders.关键词
神经病理性疼痛/放疗/普瑞巴林/肝癌/骨转移/生存质量Key words
Neuropathic pain/Radiotherapy/Pregabalin/Hepatocellular carcinoma/Bone metastasis/Quality of life分类
医药卫生引用本文复制引用
童金龙,田小强,李英,鲁世慧,王礼学,王海玉..放疗联合普瑞巴林治疗肝癌骨转移神经病理性疼痛的疗效及生存质量评价[J].肿瘤防治研究,2023,50(12):1214-1220,7.基金项目
Nanjing Medical Science and Technology Development Foundation(No.YKK18148)南京市医学科技发展资金项目(YKK18148) （No.YKK18148）
