中国现代医生2024，Vol.62Issue(1)：63-69,7.DOI:10.3969/j.issn.1673-9701.2024.01.016
基于网络药理学研究补阳还五汤治疗脊髓损伤的作用机制
Mechanism of Buyang Huanwu decoction in the treatment of spinal cord injury based on network pharmacology
摘要
Abstract
Objective To verify the mechanism of Buyang Huanwu decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking.Methods The active ingredients and targets of Buyang Huanwu decoction were screened out by TCMSP,SymMap,PubChem and Swiss Target Prediction databases.Spinal cord injury targets were retrieved from OMIM,GeneCards,TTD,and DrugBank databases.Through venny software,the intersection target of Buyang Huanwu decoction and spinal cord injury was obtained.The active ingredient-target network for the treatment of spinal cord injury was constructed with Cytoscape software.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of common targets were carried out by DAVID,and the binding ability of drugs and targets was analyzed by molecular docking technology.Results A total of 106 active ingredients and 225 targets of Buyang Huanwu decoction,1315 targets of spinal cord injury and 112 targets of drug-disease intersection were obtained.The active ingredients of Buyang Huanwu decoction were quercetin,kaempferol,ellagic acid,luteolin and hederagenin in the treatment of spinal cord injury.Conclusion Buyang Huanwu decoction can achieve the purpose of treating spinal cord injury through various signal pathways.关键词
补阳还五汤/脊髓损伤/网络药理学/作用机制/分子对接Key words
Buyang Huanwu decoction/Spinal cord injury/Network pharmacology/Mechanism of action/Molecular docking分类
医药卫生引用本文复制引用
钟木森,安忠诚,樊光亚,暴纪谦,苏文硕,董黎强..基于网络药理学研究补阳还五汤治疗脊髓损伤的作用机制[J].中国现代医生,2024,62(1):63-69,7.基金项目
浙江省中医药科技计划项目(2021ZA075) （2021ZA075）
