内科2023，Vol.18Issue(6)：518-520,3.DOI:10.16121/j.cnki.cn45-1347/r.2023.06.02
血浆同型半胱氨酸水平与大肠癌的相关性
Correlation between the plasma homocysteine level and colorectal carcinoma
摘要
Abstract
Objective To investigate the correlation between the plasma homocysteine(Hcy)level and colorectal carcinoma.Methods A total of 81 patients with colorectal carcinoma(colorectal carcinoma group),52 patients with dysplastic colorectal polyps(dysplastic colorectal polyps group),and 54 patients with dysplasia-free colorectal polyps(dysplasia-free colorectal polyps group)were enrolled as research objects.The plasma Hcy levels of the three groups were compared,the binary logistic regression model was used to analyze the influencing factors for the incidence of colorectal carcinoma,and the receiver operating characteristic(ROC)curve was drawn to evaluate the value of the plasma Hcy level in predicting the incidence of colorectal carcinoma.Results The plasma Hcy level in the colorectal carcinoma group was higher than that in the dysplasia-free colorectal polyps group and the dysplastic colorectal polyps group(all P＜0.05),and the plasma Hcy level was an independent influencing factor for the incidence of colorectal carcinoma(P＜0.05).The results of the ROC curve analysis showed that the area under the ROC curve of plasma Hcy level for predicting colorectal carcinoma was 0.614,and the optimal cut-off value was 15.25 μmol/L(sensitivity and specificity were 50.0％and 71.4％,respectively).Conclusions The plasma Hcy level in colorectal carcinoma patients is significantly increased,and the elevated plasma Hey level is an independent risk factor for the incidence of colorectal carcinoma.关键词
血浆同型半胱氨酸/大肠息肉/大肠癌/预测Key words
Plasma homocysteine/Colorectal polyp/Colorectal carcinoma/Prediction分类
医药卫生引用本文复制引用
方文慧,豆正莉,郑可佳..血浆同型半胱氨酸水平与大肠癌的相关性[J].内科,2023,18(6):518-520,3.基金项目
安徽医科大学校临床科学基金(2022xkj207) （2022xkj207）
