内科2023，Vol.18Issue(6)：521-525,5.DOI:10.16121/j.cnki.cn45-1347/r.2023.06.03
肿瘤相关中性粒细胞和上皮-间质转化在结直肠癌中的临床病理意义
Clinicopathological significance of tumor-associated neutrophil and epithelial-mesenchymal transition in colorectal cancer
摘要
Abstract
Objective To investigate the clinicopathological significance of tumor-associated neutrophil(TAN)and epithelial-mesenchymal transition(EMT)in colorectal cancer(CRC).Methods The medical records of 100 patients with CRC who were followed up for more than 5 years were retrospectively analyzed.Hematoxylin-eosin staining was used to detect TAN infiltration,immunohistochemistry was used to detect the expressions of EMT markers(E-cadherin and vimentin),Kaplan-Meier survival curve was used to compare the survival of CRC patients with different TAN infiltration conditions,and Spearman's correlation analysis was used to explore the correlations between TAN infiltration and EMT markers'expressions.Results Of the 100 CRC patients,29 had TAN infiltration in CRC tissues.The immunohistochemical staining score of E-cadherin in CRC tissues was lower than that in normal pericarcinous tissues,and the immunohistochemical staining score of vimentin in CRC tissues was higher than that in normal pericarcinous tissues(all P＜0.05).The TNM stage and lymph node metastasis of CRC patients with TAN infiltration were worse than those without TAN infiltration(all P＜0.05).The results of the Kaplan-Meier survival curve analysis showed that the cumulative survival rate of CRC patients with TAN infiltration was lower than that of CRC patients without TAN infiltration(P＜0.05).The results of Spearman's correlation analysis showed that TAN infiltration was negatively correlated with the E-cadherin expression(rs=-0.498,P＜0.05)but was positively correlated with the vimentin expression(rs=0.611,P＜0.05).Conclusions TAN infiltration is negatively correlated with the E-cadherin expression but is positively correlated with the vimentin expression;TAN may promote the growth and metastasis of CRC by participating in the EMT process.关键词
肿瘤相关中性粒细胞/上皮-间质转化/结直肠癌/上皮钙黏素/波形蛋白Key words
Tumor-associated neutrophil/Epithelial-mesenchymal transition/Colorectal cancer/E-cadherin/Vimentin分类
医药卫生引用本文复制引用
吴共发,邱丽浈,曾宇婷,刘钰君,赖剑龙,姚金科..肿瘤相关中性粒细胞和上皮-间质转化在结直肠癌中的临床病理意义[J].内科,2023,18(6):521-525,5.基金项目
广东省广州市科技计划项目(202002030450,202102080560,202102080542),广东省医学科研基金面上项目(B2021018) （202002030450,202102080560,202102080542）
