中国现代医生2023，Vol.61Issue(35)：17-22,6.DOI:10.3969/j.issn.1673-9701.2023.35.005
磁共振参数及TNF-α、IL-1α水平在阿尔兹海默病中的诊断价值研究
The diagnostic value and correlation of magnetic resonance parameters with TNF-α and IL-1α levels in Alzheimer's disease
摘要
Abstract
Objective To explore the diagnostic value of magnetic resonance DKI parameters and serum levels of tumor necrosis factor-alpha(TNF-α)and interleukin-1α(IL-1α)in Alzheimer's disease(AD).Methods From July 2020 to July 2022,60 patients with Alzheimer's disease in our hospital were selected as the observation group and 60 healthy elderly people over 60 years old as the control group.All patients underwent routine MRI sequence examination,measured DKI parameters,and detected serum TNF-α and IL-1α levels by ELISA.Results The MD value of each brain area was significantly increased in alzheimer's disease patients.FA of white matter,hippocampus and substantia nigra decreased in temporal and parietal cortex,while FA of caudate nucleus,red nucleus and dentate nucleus increased.RK of white matter,hippocampus and thalamus in temporal and parietal cortex decreased significantly,while RK in substantia nigra increased significantly.AK of white matter,thalamus,dentate nucleus and substantia nigra in temporal and parietal cortex were significantly decreased.The MK in white matter,hippocampus and thalamus of temporal and parietal cortex decreased significantly,while the MK in caudate nucleus and substantia nigra increased significantly.The serum levels of homotype hemisoline and acetylcholinesterase increased significantly.Conclusion Combined magnetic resonance DKI parameters and detection of serum TNF-α and IL-1α levels have certain diagnostic and predictive value for the occurrence of Alzheimer's disease.关键词
阿尔兹海默病/DKI参数/肿瘤坏死因子-α/白细胞介素 1αKey words
Alzheimer's disease/DKI parameters/TNF-α/IL-1α分类
医药卫生引用本文复制引用
余梁俊,凌迎春..磁共振参数及TNF-α、IL-1α水平在阿尔兹海默病中的诊断价值研究[J].中国现代医生,2023,61(35):17-22,6.基金项目
浙江省医药卫生科技计划项目(2022KY1309) （2022KY1309）
