中国中西医结合外科杂志2023，Vol.29Issue(6)：741-745,5.DOI:10.3969/j.issn.1007-6948.2023.06.004
超声清创联合去腐生新膏治疗慢性下肢静脉性溃疡的临床疗效
Observation on effect of Ultrasonic debridement combined with Qufu Shengxin ointment in the treatment of lower limb venous ulcers
摘要
Abstract
Objective To observe the effect of Ultrasonic debridement combined with Qufu Shengxin ointment in the treatment of lower limb venous ulcers.Methods 66 patients with chronic lower limb venous ulcers were selected and divided into 2 groups,experimental group and control group,according to the random method,33 cases in each group.After admission,both groups were treated with conventional basic treatment combined with ultrasonic debridement for wound cleaning.Experimental group was treated with Qufu Shengxin ointment,control group with recombinant human basic fibroblast growth factor.Clinical indexes(Occurrence time of fresh granulation,healing days,wound bacterial clearance rate,pain,swelling,skin adverse reaction rate,ulcer area,ulcer depth),inflammation and cytokines[C-reactive protein(CRP),hypoxia-inducing factor(HIF-1α),vascular endothelial growth factor(VEGF)],lankle brachial index(ABI),transcutaneous pressure of owimetry(tcpO2)and vibration perception threshold(VPT)were observed and analyzed in two groups.Results After the treatment,all of these indicators have improved(P＜0.05).The occurrence time of fresh granulation and healing time in experimental group were significantly better than those in control group(P＜0.01).After 7 days treatment,pain score and swelling range were improved compared with control group(P＜0.05).After 14 days treatment,there were no significant differences in pain score,swelling range,ABI,wound bacterial clearance rate and skin adverse reactions between the two groups(P＞0.05).The improvement of CRP,VEGF,HIF-α,tcpO2 and VPT in experimental group was better than that in control group(P＜0.05).Conclusion Ultrasonic debridement combined with Qufu Shengxin ointment in the treatment of lower limb venous ulcers has better clinical effect,can significantly relieve ulcer symptoms,shorten ulcer healing time,improve wound microenvironment and lower limb circulation,and do not increase skin adverse reactions.关键词
超声清创/去腐生新膏/慢性下肢静脉性溃疡Key words
Ultrasonic debridement/Qufu Shengxin ointment/lower limb venous ulcers分类
医药卫生引用本文复制引用
陈海东,陈德轩,方勇,李逸梅,杨旭,龚旭初..超声清创联合去腐生新膏治疗慢性下肢静脉性溃疡的临床疗效[J].中国中西医结合外科杂志,2023,29(6):741-745,5.基金项目
南京中医药大学自然科学基金(XZR2021084) （XZR2021084）
南通市卫健委青年基金(A类)(QA2020012) （A类）
第七批全国名老中医师承项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
国家中医药管理局重点专科项目(国中医药办医政函[2019]210号) （国中医药办医政函[2019]210号）
南通市"十四五"科教强卫工程临床医学中心及青年医学重点人才项目(通卫科教[2021]15号) （通卫科教[2021]15号）
