中医药学报2024，Vol.52Issue(1)：116-122,7.DOI:10.19664/j.cnki.1002-2392.240021
姜黄素调控肿瘤干细胞干性的分子机制及研究进展
Molecular Mechanism and Research Progress of Curcumin Regulating Stemness in Cancer Stem Cells
摘要
Abstract
Cancer stem cells(CSCs)are considered to be the key points of cancer treatment,and they have unique characteristics of surface markers,stem-related signaling pathways,epigenetic and immunochemotactic factors,which are highly correlated with tumor initiation,recurrence,metastasis and drug resistance.Curcumin is a kind of polyphenol extracted from the rhizome of curcuma.It has a wide range of anticancer effects,including promoting tumor cell apoptosis,inhibiting tumor invasion,reversing chemotherapy resistance and regulating immune microenvironment.It also shows great potential in inhibiting the stemness of CSCs.Starting from the regulatory effect of curcumin on the stemness of CSCs,this article summarizes its clinical application potential and advantages,and comprehensively reviews the effect of curcumin on the stemness of CSCs from the four perspectives of stem-related signaling pathway,epigenetics,tumor microenvironment and targeted preparations,aiming to provide a theoretical basis for the treatment of tumors with CSCs.关键词
姜黄素/肿瘤干细胞/干性/分子机制Key words
Curcumin/Cancer stem cells/Stemness/Molecular mechanism分类
中医学引用本文复制引用
褚欣虹,刘亮,钟敏,孙玉姣,郭琳,葛军,付慧,李英鹏..姜黄素调控肿瘤干细胞干性的分子机制及研究进展[J].中医药学报,2024,52(1):116-122,7.基金项目
国家自然科学基金青年科学基金项目(82104568) （82104568）
天津市教委科研计划项目(2020KJ195) （2020KJ195）
天津市科技计划项目(21JCQNJC01740) （21JCQNJC01740）
天津市研究生科研创新项目(2022SKY230) （2022SKY230）
天津中医药大学研究生科研创新项目(YJSKC-20221039) （YJSKC-20221039）
