姜黄素调控肿瘤干细胞干性的分子机制及研究进展OACSTPCD

Cancer stem cells(CSCs)are considered to be the key points of cancer treatment,and they have unique characteristics of surface markers,stem-related signaling pathways,epigenetic and immunochemotactic factors,which are highly correlated with tumor initiation,recurrence,metastasis and drug resistance.Curcumin is a kind of polyphenol extracted from the rhizome of curcuma.It has a wide range of anticancer effects,including promoting tumor cell apoptosis,inhibiting tumor invasion,reversing chemotherapy resistance and regulating immune microenvironment.It also shows great potential in inhibiting the stemness of CSCs.Starting from the regulatory effect of curcumin on the stemness of CSCs,this article summarizes its clinical application potential and advantages,and comprehensively reviews the effect of curcumin on the stemness of CSCs from the four perspectives of stem-related signaling pathway,epigenetics,tumor microenvironment and targeted preparations,aiming to provide a theoretical basis for the treatment of tumors with CSCs.