中国中医药信息杂志2024，Vol.31Issue(1)：191-196,6.DOI:10.19879/j.cnki.1005-5304.202212451
中药调控JAK/STAT信号通路干预心肌缺血再灌注损伤作用机制研究进展
Research Progress in the Mechanism of TCM for Regulating JAK/STAT Signaling Pathway in Intervention of Myocardial Ischemia-reperfusion Injury
摘要
Abstract
Acute myocardial infarction(AMI)is a common cardiovascular emergency in clinic.Early reperfusion is a typical and effective method for the treatment of AMI.However,the recovery of blood supply after reperfusion therapy will accelerate the damage of ischemic myocardium and cause myocardial ischemia-reperfusion injury(MI/RI).In recent years,studies have found that TCM has the unique advantages of multi-component,multi-channel and multi-target in the intervention of MI/RI.Janus tyrosine kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway is closely related to MI/RI,which can reduce MI/RI process by regulating inflammation,oxidative stress,cell proliferation,differentiation and apoptosis.This article reviewed the mechanism of JAK/STAT signaling pathway in MI/RI and the research of TCM targeting this pathway,in order to provide references for the prevention and treatment of MI/RI and further drug development.关键词
中药/JAK/STAT信号通路/心肌缺血再灌注损伤/综述Key words
TCM/JAK/STAT signaling pathway/myocardial ischemia-reperfusion injury/review分类
医药卫生引用本文复制引用
赵晓彬,王新强,蒋虎刚,韩金晏,张晓刚,李应东,赵信科..中药调控JAK/STAT信号通路干预心肌缺血再灌注损伤作用机制研究进展[J].中国中医药信息杂志,2024,31(1):191-196,6.基金项目
中医药传承与创新"百千万"人才工程(岐黄工程)青年岐黄学者支持项目(001079002) （岐黄工程）
甘肃省"双一流"科研重点项目专项开放课题(GSSYLXM-05-ZXYJH-5) （GSSYLXM-05-ZXYJH-5）
陇原青年创新创业人才项目(2022年) （2022年）
甘肃中医药大学附属医院院内课题(gzfy-2022-10) （gzfy-2022-10）
