中国肿瘤生物治疗杂志2023，Vol.30Issue(12)：1035-1042,8.DOI:10.3872/j.issn.1007-385x.2023.12.001
RNA N7-甲基鸟苷甲基化修饰在肿瘤发生发展中的作用
The role of RNA m7G modification in tumorigenesis and tumor development
摘要
Abstract
N7-methylguanosine(m7G)is one of the most common RNA modifications in epigenetic regulation,it plays an important role in the processing and metabolism of a variety of RNA molecules such as messenger RNAs(mRNAs),ribosomal RNAs(rRNAs),transfer RNAs(tRNAs)and microRNAs,and thus participates in many cellular processes such as cell proliferation,differentiation,apoptosis and migration.Increasing evidence suggests that m7G methylation is involved in tumorigenesis and tumor development.The abnormal m7G methylation is closely related to tumor development and progression by regulating the expression of multiple oncogenes and tumor suppressor genes,to promote or inhibit,the progression of various types of tumors.Molecules modified by m7G methylation and their regulators can be potential targets for tumor diagnosis and therapy.In this article,the recent advances in m7G modifications,the detection methods of m7G modification and the potential molecular mechanisms of the role of m7G modification in tumorigenesis and tumor development cancer are reviewed.关键词
RNA表观遗传修饰/N7-甲基鸟苷(m7G)/RNA m7G甲基化修饰酶/肿瘤Key words
RNA epigenetic modification/N7-methylguanosine(m7G)/RNA m7G methyltransferases/tumor分类
生物科学引用本文复制引用
钱永美,徐克..RNA N7-甲基鸟苷甲基化修饰在肿瘤发生发展中的作用[J].中国肿瘤生物治疗杂志,2023,30(12):1035-1042,8.基金项目
国家自然科学基金(No.81372519) （No.81372519）
天津市自然科学基金重点项目(No.22JCZDJC00450) （No.22JCZDJC00450）
天津市卫生健康委员会科技项目(No.TJWJ2021MS006) （No.TJWJ2021MS006）
天津市医学重点学科(专科)建设项目(No.TJYXZDXK-061B) （专科）
