中国现代医生2024，Vol.62Issue(1)：32-35,4.DOI:10.3969/j.issn.1673-9701.2024.01.008
血清Ang-2、I-FABP表达与急性心肌梗死合并心源性休克预后的相关性分析
The correlation between the expressions of serum Ang-2 and I-FABP and the prognosis of acute myocardial infarction with cardiac shock
摘要
Abstract
Objective To investigate the correlation between angiopoietin-2(Ang-2)and intestinal fatty acid binding protein(I-FABP)levels and the prognosis of acute myocardial infarction(AMI)with cardiac shock(CS).Methods A total of 198 patients with AMI admitted to Huzhou Central Hospital from July 2017 to July 2019 were selected as study objects,and were divided into CS group(n=93)and non-CS group(n=105)according to whether CS occurred during the hospital period,and 65 normal volunteers admitted for physical examination during the same period were included in control group.Patients in CS group were divided into survival group(n=50)and death group(n=43)according to their survival at 28 days.Serum Ang-2 and I-FABP levels of all subjects were detected,and Cox regression analysis was used to analyze the factors affecting the poor prognosis of AMI with CS.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of Ang-2 and I-FABP in AMI with CS.Results Serum Ang-2 and I-FABP levels in CS group were significantly higher than those in non-CS group and control group(P<0.05),and serum Ang-2 and I-FABP levels in non-CS group were significantly higher than those in control group(P<0.05).Serum Ang-2,I-FABP levels and proportion of diabetes in death group were significantly higher than those in survival group(P<0.05).Cox regression analysis showed that diabetes,Ang-2 and I-FABP levels were independent factors affecting the prognosis of AMI with CS(P<0.05).ROC curve showed that the area under the curve of Ang-2 and I-FABP combined to predict the prognosis of AMI with CS was 0.819,sensitivity was 81.4%,specificity was 80.0%.Conclusion Serum Ang-2 and I-FABP levels were elevated in patients with AMI with CS,which were potential biological indicators to predict the prognosis of patients.关键词
急性心肌梗死/心源性休克/血管生成素2/肠脂肪酸结合蛋白/预后Key words
Acute myocardial infarction/Cardiac shock/Angiopoietin-2/Intestinal fatty acid binding protein/Prognosis分类
医药卫生引用本文复制引用
王东,许岚,夏森林,孙越晨,王伟..血清Ang-2、I-FABP表达与急性心肌梗死合并心源性休克预后的相关性分析[J].中国现代医生,2024,62(1):32-35,4.基金项目
浙江省湖州市科学技术局公益性应用研究项目(2019GYB13) （2019GYB13）
